Zmener O, Guglielmotti M B, Cabrini R L
Department of Oral Pathology, Faculty of Odontology, University of Buenos Aires.
Endod Dent Traumatol. 1990 Apr;6(2):66-72. doi: 10.1111/j.1600-9657.1990.tb00393.x.
Silicone tubes containing a freshly mixed experimental Sealapex, in which titanium dioxide was removed from the original formula, were implanted in the dorsal subcutaneous connective tissue of the rat. Solid silicone rods of the same size as the tubes were also implanted and used as inert controls. The tissue reaction to both these materials was histometrically and quantitatively studied under light microscopy and by elemental electron microprobe analysis. After 7, 30 and 90 d of implantation, different grades of tissue reaction to the tested materials were recorded. A granulomatous tissue containing numerous foreign-body giant cells and macrophages with engulfed particles in their cytoplasms was initially detected in contact with the test material. In addition, many fibroblasts and newly formed vessels were also observed at these areas. The results of this study revealed that these reactions increased progressively at the 30- and 90-d observations. The electron microprobe analysis of the granulomatous tissues showed the presence of heavy components of the experimental material.
将含有新混合的实验性Sealapex（其中二氧化钛已从原始配方中去除）的硅胶管植入大鼠背部皮下结缔组织。还植入了与管子尺寸相同的实心硅胶棒，并用作惰性对照。在光学显微镜下和通过元素电子微探针分析，对这两种材料的组织反应进行了组织计量学和定量研究。植入7、30和90天后，记录了对测试材料的不同程度的组织反应。最初在与测试材料接触处检测到含有大量异物巨细胞和巨噬细胞的肉芽肿组织，巨噬细胞的细胞质中含有吞噬的颗粒。此外，在这些区域还观察到许多成纤维细胞和新形成的血管。这项研究的结果表明，在30天和90天的观察中，这些反应逐渐增加。对肉芽肿组织的电子微探针分析显示存在实验材料的重成分。
