蜂王浆中的组蛋白去乙酰化酶抑制剂活性可能有助于蜜蜂的蜂级转换。
Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees.
机构信息
Department of Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Park Road 1C, Smithville, Texas 78957, USA.
出版信息
EMBO Rep. 2011 Mar;12(3):238-43. doi: 10.1038/embor.2011.9. Epub 2011 Feb 18.
Abstract
Worker and queen bees are genetically indistinguishable. However, queen bees are fertile, larger and have a longer lifespan than their female worker counterparts. Differential feeding of larvae with royal jelly controls this caste switching. There is emerging evidence that the queen-bee phenotype is driven by epigenetic mechanisms. In this study, we show that royal jelly--the secretion produced by the hypopharyngeal and mandibular glands of worker bees--has histone deacetylase inhibitor (HDACi) activity. A fatty acid, (E)-10-hydroxy-2-decenoic acid (10HDA), which accounts for up to 5% of royal jelly, harbours this HDACi activity. Furthermore, 10HDA can reactivate the expression of epigenetically silenced genes in mammalian cells. Thus, the epigenetic regulation of queen-bee development is probably driven, in part, by HDACi activity in royal jelly.
摘要
工蜂和蜂王在基因上无法区分。然而，蜂王具有生育能力，体型更大，寿命比其雌性工蜂长。幼虫用蜂王浆进行不同的喂养可以控制这种级型转换。有新的证据表明，蜂王表型是由表观遗传机制驱动的。在这项研究中，我们表明，蜂王浆——工蜂的下咽腺和下颌腺分泌的物质——具有组蛋白去乙酰化酶抑制剂 (HDACi) 的活性。一种脂肪酸，（E）-10-羟基-2-癸烯酸（10HDA），占蜂王浆的 5%，具有这种 HDACi 活性。此外，10HDA 可以使哺乳动物细胞中被表观遗传沉默的基因重新表达。因此，蜂王发育的表观遗传调控可能部分由蜂王浆中的 HDACi 活性驱动。
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