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植酸在细胞培养模型中可防止正常和铁过载条件下 6-羟多巴胺诱导的多巴胺能神经元凋亡。

Phytic Acid Protects against 6-Hydroxydopamine-Induced Dopaminergic Neuron Apoptosis in Normal and Iron Excess Conditions in a Cell Culture Model.

机构信息

Foreign Language Center, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

出版信息

Parkinsons Dis. 2011 Feb 7;2011:431068. doi: 10.4061/2011/431068.

DOI:10.4061/2011/431068
PMID:21331377
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3038597/
Abstract

Iron may play an important role in Parkinson's disease (PD) since it can induce oxidative stress-dependent neurodegeneration. The objective of this study was to determine whether the iron chelator, phytic acid (IP6) can protect against 6-hydroxydopamine- (6-OHDA-) induced apoptosis in immortalized rat mesencephalic dopaminergic cells under normal and iron-excess conditions. Caspase-3 activity was increased about 6-fold after 6-OHDA treatment (compared to control; P < .001) and 30 μmol/L IP6 pretreatment decreased it by 38% (P < .05). Similarly, a 63% protection (P < .001) against 6-OHDA induced DNA fragmentation was observed with IP6 pretreatment. Under iron-excess condition, a 6-fold increase in caspase-3 activity (P < .001) and a 42% increase in DNA fragmentation (P < .05) with 6-OHDA treatment were decreased by 41% (P < .01) and 27% (P < .05), respectively, with 30 μmol/L IP6. Together, our data suggest that IP6 protects against 6-OHDA-induced cell apoptosis in both normal and iron-excess conditions, and IP6 may offer neuroprotection in PD.

摘要

铁可能在帕金森病 (PD) 中起重要作用，因为它可以诱导依赖氧化应激的神经退行性变。本研究的目的是确定铁螯合剂植酸 (IP6) 是否可以在正常和铁过量条件下防止 6-羟多巴胺 (6-OHDA) 诱导的永生大鼠中脑多巴胺能细胞凋亡。6-OHDA 处理后 caspase-3 活性增加约 6 倍 (与对照相比; P <.001)，30μmol/L IP6 预处理降低了 38% (P <.05)。同样，IP6 预处理对 6-OHDA 诱导的 DNA 片段化有 63%的保护作用 (P <.001)。在铁过量条件下，6-OHDA 处理后 caspase-3 活性增加 6 倍 (P <.001)，DNA 片段化增加 42% (P <.05)，分别降低 41% (P <.01)和 27% (P <.05)与 30μmol/L IP6。总之，我们的数据表明，IP6 可在正常和铁过量条件下防止 6-OHDA 诱导的细胞凋亡，IP6 可能在 PD 中提供神经保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6849/3038597/2725bd557401/PD2011-431068.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6849/3038597/8ccf97ab8eb0/PD2011-431068.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6849/3038597/2725bd557401/PD2011-431068.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6849/3038597/8ccf97ab8eb0/PD2011-431068.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6849/3038597/2725bd557401/PD2011-431068.002.jpg

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