Department of Ophthalmology, Columbia University, New York City, New York 10032, USA.
Acta Ophthalmol. 2011 Aug;89(5):e404-11. doi: 10.1111/j.1755-3768.2011.02123.x. Epub 2011 Feb 18.
The Nidek F-10 is a scanning laser ophthalmoscope that is capable of a novel fundus imaging technique, so-called 'retro-mode' imaging. The standard method of imaging drusen in age-related macular degeneration (AMD) is by fundus photography. The aim of the study was to assess drusen quantification using retro-mode imaging.
Stereoscopic fundus photographs and retro-mode images were captured in 31 eyes of 20 patients with varying stages of AMD. Two experienced masked retinal graders independently assessed images for the number and size of drusen, using purpose-designed software. Drusen were further assessed in a subset of eight patients using optical coherence tomography (OCT) imaging.
Drusen observed by fundus photography (mean 33.5) were significantly fewer in number than subretinal deposits seen in retro-mode (mean 81.6; p < 0.001). The predominant deposit diameter was on average 5 μm smaller in retro-mode imaging than in fundus photography (p = 0.004). Agreement between graders for both types of imaging was substantial for number of deposits (weighted κ = 0.69) and moderate for size of deposits (weighted κ = 0.42). Retro-mode deposits corresponded to drusen on OCT imaging in all eight patients.
The subretinal deposits detected by retro-mode imaging were consistent with the appearance of drusen on OCT imaging; however, a larger longitudinal study would be required to confirm this finding. Retro-mode imaging detected significantly more deposits than conventional colour fundus photography. Retro-mode imaging provides a rapid non-invasive technique, useful in monitoring subtle changes and progression of AMD, which may be useful in monitoring the response of drusen to future therapeutic interventions.
尼德克 F-10 是一种扫描激光检眼镜，能够进行一种新颖的眼底成像技术，即所谓的“回溯模式”成像。年龄相关性黄斑变性（AMD）中 黄斑 病变的标准成像方法是眼底照相。本研究的目的是评估回溯模式成像在检测 黄斑 病变中的应用。
对 20 名不同阶段 AMD 患者的 31 只眼进行立体眼底照相和回溯模式成像。两名经验丰富的盲法视网膜分级医师使用专门设计的软件，分别对图像中的 黄斑 病变数量和大小进行独立评估。在 8 名患者的亚组中，使用光学相干断层扫描（OCT）成像进一步评估 黄斑 病变。
眼底照相观察到的 黄斑 病变（平均 33.5 个）数量明显少于回溯模式下观察到的视网膜下沉积物（平均 81.6 个；p < 0.001）。回溯模式成像中，沉积物的主要直径平均比眼底照相小 5μm（p = 0.004）。两种成像方式的分级医师之间的一致性在沉积物数量方面较高（加权κ=0.69），在沉积物大小方面中等（加权κ=0.42）。在所有 8 名患者中，回溯模式下的沉积物与 OCT 成像上的 黄斑 病变相对应。
回溯模式成像检测到的视网膜下沉积物与 OCT 成像上的 黄斑 病变外观一致；然而，需要进行更大的纵向研究来确认这一发现。回溯模式成像比传统的彩色眼底照相检测到更多的沉积物。回溯模式成像提供了一种快速、非侵入性的技术，可用于监测 AMD 的细微变化和进展，这可能有助于监测 黄斑 病变对未来治疗干预的反应。
