Savastano Maria Cristina, Fossataro Claudia, Sadun Riccardo, Scupola Andrea, Sammarco Maria Grazia, Rizzo Clara, Pafundi Pia Clara, Rizzo Stanislao
Ophthalmology Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy.
Ophthalmology Unit, Catholic University of the Sacred Heart, 00168 Rome, Italy.
Life (Basel). 2023 Jun 17;13(6):1407. doi: 10.3390/life13061407.
The aim of our study was to investigate the clinical features of central serous chorioretinopathy (CSC) with autofluorescence (AF), retromode (RM), and enface imaging. This retrospective study was conducted at Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome (Italy), between September and December 2022. Each patient underwent a complete ophthalmological examination, which included optical coherence tomography (OCT), enface image analysis, AF, and RM imaging. We further evaluated the presence and area of extension of serous retinal detachment and retinal pigment epithelium (RPE) atrophy through AF, RM, and enface imaging. We included 32 eyes from 27 patients (mean age: 52.7 ± 13.3 years). The median AF area was 19.5 mm (IQR 6.1-29.3), while the median RM area was 12.3 mm (IQR 8.1-30.8), and the median enface area was 9.3 mm (IQR 4.8-18.6). RPE atrophy was diagnosed in 26 cases (81.3%) with RM imaging and in 75% of cases with AF. No difference emerged between AF and RM analysis in the detection of central serous detachment in CSC. However, RM imaging showed a high specificity (91.7%) and negative predictive value (84.6%) to detect RPE changes when compared to the AF standard-of-care technique. Thus, RM imaging could be considered an adjunctive imaging method in CSC.
我们研究的目的是通过自发荧光（AF）、后向模式（RM）和正面成像来研究中心性浆液性脉络膜视网膜病变（CSC）的临床特征。这项回顾性研究于2022年9月至12月在意大利罗马的圣心天主教大学综合医院基金会（Fondazione Policlinico Universitario A. Gemelli, IRCCS）进行。每位患者都接受了全面的眼科检查，包括光学相干断层扫描（OCT）、正面图像分析、AF和RM成像。我们通过AF、RM和正面成像进一步评估了浆液性视网膜脱离和视网膜色素上皮（RPE）萎缩的存在及扩展区域。我们纳入了27例患者的32只眼（平均年龄：52.7±13.3岁）。AF面积中位数为19.5 mm（四分位间距6.1 - 29.3），而RM面积中位数为12.3 mm（四分位间距8.1 - 30.8），正面面积中位数为9.3 mm（四分位间距4.8 - 18.6）。通过RM成像在26例（81.3%）病例中诊断出RPE萎缩，通过AF在75%的病例中诊断出RPE萎缩。在CSC中心性浆液性脱离的检测中，AF和RM分析之间没有差异。然而，与AF标准护理技术相比，RM成像在检测RPE变化方面显示出高特异性（91.7%）和阴性预测值（84.6%）。因此，RM成像可被视为CSC的一种辅助成像方法。
