Department of Ophthalmology, Medicine of Sensory Function, Ehime University Graduate School of Medicine, Toon, Japan.
Am J Ophthalmol. 2011 May;151(5):782-791.e1. doi: 10.1016/j.ajo.2010.10.033. Epub 2011 Feb 18.
To evaluate the newly developed Ocular Surface Thermographer (TOMEY Corporation) for dry eye screening.
Prospective, controlled study.
We studied 30 eyes of 30 patients diagnosed with dry eye (mean age ± standard deviation, 52.9 ± 17.1 years) and 30 eyes of 30 normal subjects (42.7 ± 17.0 years). The ocular surface temperature was measured immediately after eye opening and every second during 10 seconds of eye opening. The reliability of the measurements was determined by calculating intraclass correlation coefficients. Then, the correlations between the change in the ocular surface temperature and tear film break-up time, Schirmer I test values, and fluorescein staining scores were determined.
The measurements of the ocular surface temperature had a high degree of reliability. Immediately after eye opening, the temperature in the dry eye did not differ significantly from that in normal eyes in any of the 3 regions tested. The decrease in the ocular surface temperature in dry eyes was significantly greater than that in normal eyes (P < .001) at 10 seconds after eye opening. The decrease in the temperature of the cornea was correlated significantly with the tear film break-up time (r = -0.572; P < .001). When the changes in ocular surface temperature of the cornea were used as an index for dry eye, the sensitivity was 0.83 and the specificity was 0.80 after 10 seconds.
Measurements of the ocular surface temperature obtained with our newly developed Ocular Surface Thermographer after 10 seconds of eye opening may provide a simple, noninvasive screening test for dry eyes.
评估新开发的眼部表面热图仪（TOMEY 公司）用于干眼症筛查。
前瞻性、对照研究。
我们研究了 30 例干眼症患者（平均年龄±标准差，52.9±17.1 岁）的 30 只眼和 30 例正常受试者（42.7±17.0 岁）的 30 只眼。在睁眼后即刻和睁眼后 10 秒内每 2 秒测量眼表面温度。通过计算组内相关系数来确定测量的可靠性。然后，确定眼表面温度变化与泪膜破裂时间、Schirmer I 试验值和荧光素染色评分之间的相关性。
眼表面温度的测量具有高度可靠性。在睁眼后即刻，在测试的 3 个区域中，干眼症患者的眼温度与正常眼无显著差异。在睁眼后 10 秒时，干眼症患者的眼表面温度下降明显大于正常眼（P<0.001）。角膜眼表面温度的降低与泪膜破裂时间呈显著相关（r=-0.572；P<0.001）。当使用角膜眼表面温度变化作为干眼症的指标时，在 10 秒后，其灵敏度为 0.83，特异性为 0.80。
使用我们新开发的眼部表面热图仪在睁眼后 10 秒测量眼表面温度，可能提供一种简单、非侵入性的干眼症筛查试验。
