RNA 在人类细胞基因转录调控中的新兴作用。
The emerging role of RNA in the regulation of gene transcription in human cells.
机构信息
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, United States.
出版信息
Semin Cell Dev Biol. 2011 Jun;22(4):351-8. doi: 10.1016/j.semcdb.2011.02.017. Epub 2011 Feb 17.
Abstract
Recent evidence suggests that particular species of non-coding RNAs can modulate gene transcription in human cells. While such observations were in the past relegated to imprinted genes, it is now becoming apparent that several different genes in differentiated cells may be under some form of RNA based regulatory control. Studies carried out to date have begun to discern the mechanism of action whereby non-coding RNAs modulate gene transcription by the targeted recruitment of epigenetic silencing complexes to homology containing loci in the genome. The results of these studies will be considered in detail as well as the implications that a vast array of non-coding RNA based regulatory networks may be operative in human cells.
摘要
最近的证据表明，特定种类的非编码 RNA 可以调节人类细胞中的基因转录。虽然过去这些观察结果仅限于印记基因，但现在越来越明显的是，分化细胞中的几个不同基因可能受到某种基于 RNA 的调控。迄今为止进行的研究已经开始辨别非编码 RNA 通过靶向募集表观遗传沉默复合物到基因组中同源性包含的基因座来调节基因转录的作用机制。这些研究的结果将被详细考虑，以及大量基于非编码 RNA 的调控网络可能在人类细胞中起作用的影响也将被考虑。
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