血管白细胞介素-10：子痫前期的保护作用。
Vascular IL-10: a protective role in preeclampsia.
机构信息
Department of Pediatrics, Women and Infants Hospital-Warren Alpert Medical School of Brown University, Providence, RI 02905, USA.
出版信息
J Reprod Immunol. 2011 Mar;88(2):165-9. doi: 10.1016/j.jri.2011.01.009. Epub 2011 Feb 18.
Abstract
IL-10 is a pregnancy compatible cytokine that plays a vital role in maintaining the balance of anti-inflammatory and pro-inflammatory milieu at the maternal-fetal interface. Recent evidence now suggests that IL-10 is a potent vascular cytokine that can blunt hypertension and inflammation-mediated vascular dysfunction. Thus, a re-evaluation of IL-10 as a cytokine supporting endovascular interactions and angiogenesis as well as blunting hypoxic-injury and preeclampsia-like features is warranted. In this review, we highlight these novel functions of IL-10 and propose that its immune-modulating and vascular functions are mutually inclusive, particularly in the context of normal gestation.
摘要
IL-10 是一种与妊娠相容的细胞因子，在维持母胎界面抗炎和促炎环境平衡方面起着至关重要的作用。最近的证据表明，IL-10 是一种有效的血管细胞因子，可减轻高血压和炎症介导的血管功能障碍。因此，有必要重新评估 IL-10 作为支持血管内相互作用和血管生成以及减轻缺氧损伤和子痫前期样特征的细胞因子。在这篇综述中，我们强调了 IL-10 的这些新功能，并提出其免疫调节和血管功能是相互包含的，特别是在正常妊娠的情况下。
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