Shimizu M, Shimizu Y, Kodama Y
Infect Immun. 1978 Sep;21(3):747-52. doi: 10.1128/iai.21.3.747-752.1978.
Experiments were carried out to investigate the effects of ambient temperatures on the induction of transmissible gastroenteritis in feeder pigs 2 to 3 months old. Pigs maintained at a high temperature (30 +/- 2 degrees C) and exposed to the virulent transmissible gastroenteritis virus did not show clinical signs of the disease during their maintenance at the high temperature. On the other hand, a sudden decrease in the ambient temperature, either before or after virus inoculation, induced severe disease in feeder pigs exposed to the virus. However, continuous maintenance of pigs at the low temperature (4 +/- 1 degrees C) tended to somewhat reduce the frequency of occurrence of signs in proportion to the length of the maintenance periods at that temperature. Pigs raised at temperatures that fluctuated between 20 +/- 2 and 4 +/- 1 degrees C every 24 h developed profuse diarrhea. The duration of clinical signs was longer in pigs maintained under the fluctuating temperatures than in those at the constantly low temperature. With one exception, antibody against transmissible gastroenteritis virus was demonstrated in sera collected from pigs both with and without clinical signs. Antibody titers obtained, however, were somewhat higher in sera collected from pigs that had developed clinical signs than in those from pigs that had endured the infection without showing signs.
开展了实验来研究环境温度对2至3月龄仔猪感染传染性胃肠炎的影响。饲养在高温环境（30±2℃）下且接触强毒传染性胃肠炎病毒的仔猪，在高温饲养期间未表现出该病的临床症状。另一方面，在病毒接种之前或之后环境温度突然下降，会使接触病毒的仔猪引发严重疾病。然而，将仔猪持续饲养在低温环境（4±1℃）下，发病症状出现的频率会随着在该温度下饲养时间的延长而有所降低。每24小时在20±2℃和4±1℃之间波动的温度环境下饲养的仔猪出现了严重腹泻。临床症状持续的时间在温度波动环境下饲养的仔猪比在持续低温环境下饲养的仔猪更长。除了一例例外情况，在出现和未出现临床症状的仔猪血清中均检测到了抗传染性胃肠炎病毒抗体。然而，出现临床症状的仔猪血清中获得的抗体效价比未出现症状但耐受感染的仔猪血清中的抗体效价略高。
