成人生长激素缺乏症生活质量评估的巴西版本（QoL-AGHDA）：四阶段翻译与验证

The brazilian version of the Quality of Life Assessment of Growth Hormone Deficiency in Adults (QoL-AGHDA): Four-stage translation and validation.

作者信息

Ribeiro-Oliveira Antônio, Mol Suélem Simão, Twiss James, Alencar Guilherme Asmar, Miranda Paulo Augusto Carvalho, Naves Luciana A, Azevedo Monalisa F, Basílio Flávia M A, Boguszewski César Luiz, Nogueira Kátia C, Vilar Lúcio, Koltowska-Haggstrom Maria, McKenna Steve P

机构信息

Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

出版信息

Arq Bras Endocrinol Metabol. 2010 Dec;54(9):833-41. doi: 10.1590/s0004-27302010000900010.

DOI:10.1590/s0004-27302010000900010

PMID:21340177

Abstract

OBJECTIVE

This study reports on the Brazilian Portuguese adaptation of the QoL-AGHDA (Quality of Life Assessment of Growth Hormone Deficiency in Adults) for use in adult growth hormone deficient (GHD) patients.

MATERIALS AND METHODS

The translation process adopted the dual panel methodology. The questionnaire was tested through field-test interviews (16 GHD patients). In the final stage, data from 120 GHD patients (81 included in a test-retest analysis) were analyzed for internal consistency, test-retest reliability, convergent validity and validity among known groups.

RESULTS

The translation panels were successful and the draft version was amended to improve the wording as a result of the field-test interviews. Cronbach's alpha was 0.90 and test-retest reliability 0.88. QoL-AGHDA scores had the expected pattern of association with NHP scale scores and QoL-AGHDA was able to differentiate significantly between patients based on patient-reported general health (p < 0.01) and QoL (p < 0.01).

CONCLUSIONS

The adaptation of the QoL-AGHDA for a Brazilian population was successful and the adapted questionnaire was shown to be reliable and valid.

摘要

目的

本研究报告了《成人生长激素缺乏症生活质量评估量表（QoL-AGHDA）》巴西葡萄牙语版的改编情况，该量表用于成年生长激素缺乏（GHD）患者。

材料与方法

翻译过程采用双盲小组法。通过现场测试访谈（16例GHD患者）对问卷进行测试。在最后阶段，对120例GHD患者的数据（81例纳入重测分析）进行分析，以评估其内部一致性、重测信度、收敛效度和已知组间效度。

结果

翻译小组工作成功，根据现场测试访谈结果对初稿进行了修改以改进措辞。Cronbach's α系数为0.90，重测信度为0.88。QoL-AGHDA评分与NHP量表评分具有预期的关联模式，并且QoL-AGHDA能够根据患者报告的总体健康状况（p < 0.01）和生活质量（p < 0.01）在患者之间进行显著区分。