从土壤真菌青霉 BCC 17468 中分离得到两个新的倍半萜二菇类化合物 fudecadiones A 和 B。

Two new drimane sesquiterpenes, fudecadiones A and B, from the soil fungus Penicillium sp. BCC 17468.

机构信息

National Center for Genetic Engineering and Biotechnology, Thailand Science Park, Klong Luang, Pathumthani, Thailand.

出版信息

Planta Med. 2011 Jan;77(1):74-6. doi: 10.1055/s-0030-1250057. Epub 2010 Jun 24.

PMID:20577947

Abstract

Two new drimane sesquiterpenoids, fudecadione A and fudecadione B (1, 2), together with the known brefeldin A (3) and fulvic acid (4), were isolated from the soil fungus Penicillium sp. BCC 17468. Chemical structures were determined based on spectroscopic evidence including 1D and 2D NMR and mass spectral data. The proposed relative stereochemistry of fudecadiones A and B was based upon NOESY spectral data and chemical means. Compounds 1 and 4 exhibited anticancer activity against MCF-7, KB, and NCI-H187, with IC (50) values in the range of 5.05-45.43 µg/mL, while compound 2 was inactive against these tumor cells. Brefeldin (3) also displayed antimalarial activity against PLASMODIUM FALCIPARUM (K1, multidrug-resistant strain), with an IC (50) value of 1.12 µg/mL.

摘要

从土壤真菌青霉属 BCC 17468 中分离得到了两个新的倍半萜二菇类化合物，分别为 fudecadione A 和 fudecadione B（1、2），以及已知的 brefeldin A（3）和富马酸（4）。基于包括 1D 和 2D NMR 以及质谱数据在内的光谱证据确定了化学结构。fudecadiones A 和 B 的相对立体化学结构是基于 NOESY 光谱数据和化学方法确定的。化合物 1 和 4 对 MCF-7、KB 和 NCI-H187 表现出抗癌活性，IC50 值在 5.05-45.43μg/mL 范围内，而化合物 2 对这些肿瘤细胞没有活性。brefeldin（3）对疟原虫 falciparum（K1，多药耐药株）也表现出抗疟活性，IC50 值为 1.12μg/mL。