Department of Anatomy & Structural Biology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Cell Signal. 2011 Aug;23(8):1225-34. doi: 10.1016/j.cellsig.2011.02.004. Epub 2011 Feb 20.
Podosomes are ventral adhesion structures prominent in cells of the myeloid lineage. A common aspect of these cells is that they are highly motile and must to traverse multiple tissue barriers in order to perform their functions. Recently podosomes have gathered attention from researchers as important cellular structures that can influence cell adhesion, motility and matrix remodeling. Adhesive and soluble ligands act via transmembrane receptors and propagate signals to the leukocyte cytoskeleton via small G proteins of the Rho family, tyrosine kinases and scaffold proteins and are able to induce podosome formation and rearrangements. Manipulation of the signals that regulate podosome formation and dynamics can therefore be a strategy to interfere with leukocyte functions in a multitude of pathological settings, such as infections, atherosclerosis and arthritis. Here, we review the major signaling molecules that act in the formation and regulation of podosomes.
足突是骨髓谱系细胞中突出的腹侧黏附结构。这些细胞的一个共同特点是它们具有很强的迁移能力，必须穿越多个组织屏障才能发挥其功能。最近，足突作为影响细胞黏附、迁移和基质重塑的重要细胞结构引起了研究人员的关注。黏附性和可溶性配体通过跨膜受体起作用，并通过 Rho 家族的小 G 蛋白、酪氨酸激酶和支架蛋白将信号传递到白细胞细胞骨架，从而能够诱导足突的形成和重排。因此，调控足突形成和动力学的信号的操纵可以成为在多种病理情况下干扰白细胞功能的策略，例如感染、动脉粥样硬化和关节炎。在这里，我们综述了在足突形成和调节中起作用的主要信号分子。
