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成人非中性粒细胞减少患者念珠菌血症的治疗——一个尴尬的事实。

Treatment of candidemia in adult patients without neutropenia--an inconvenient truth.

机构信息

Unidade de Cuidados Intensivos Polivalente, Hospital São Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, EPE, Estrada do Forte do Alto do Duque, 1449-005 Lisboa, Portugal.

出版信息

Crit Care. 2011;15(1):114. doi: 10.1186/cc9414. Epub 2011 Jan 31.

Abstract

In 2009 the Infectious Diseases Society of America reviewed the guidelines on the treatment of candidemia in non-neutropenic patients. In this document the preferred treatment was either fluconazole or an echinocandin. Amphotericin-B formulations were considered an alternative. However, careful assessment of published data showed similar efficacy between these drugs.

摘要

2009 年,美国传染病学会审查了关于非中性粒细胞减少患者念珠菌血症治疗的指南。在本文件中,首选治疗方法是氟康唑或棘白菌素类药物。两性霉素 B 制剂被认为是一种替代药物。然而,对已发表数据的仔细评估表明,这些药物的疗效相似。

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本文引用的文献

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Patterns of amphotericin B killing kinetics against seven Candida species.两性霉素B对七种念珠菌的杀菌动力学模式。
Antimicrob Agents Chemother. 2004 Jul;48(7):2477-82. doi: 10.1128/AAC.48.7.2477-2482.2004.

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