Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Am J Clin Nutr. 2011 Apr;93(4):719-26. doi: 10.3945/ajcn.110.007153. Epub 2011 Feb 23.
Limited data suggest that the effects of abdominal subcutaneous adipose tissue (SAT) on cardiovascular disease risk may depend on accompanying amounts of abdominal visceral adipose tissue (VAT).
The objective was to examine whether abdominal VAT area modifies the effects of abdominal SAT area on subclinical atherosclerosis and cardiometabolic risk factors in both whites and African Americans.
Computed tomographic measures of abdominal SAT and VAT were examined in relation to carotid intima-media thickness (cIMT) and cardiometabolic risk factor levels in 500 African American and white women in midlife. A VAT × SAT interaction term was evaluated.
The mean (±SD) age of the sample was 51.0 ± 2.9 y, and 37% were African American. Higher amounts of SAT and VAT were associated with higher cIMT, blood pressure, homeostasis model assessment insulin resistance index (HOMA-IR), and concentrations of glucose, triglycerides, and insulin and with lower concentrations of HDL cholesterol. However, in African Americans, but not in whites, higher amounts of VAT significantly attenuated associations between higher amounts of SAT and higher insulin concentrations (P for interaction = 0.032) and HOMA-IR (P for interaction = 0.011) and reversed associations with cIMT (P for interaction = 0.005) and glucose (P for interaction = 0.044).
These results suggest that in midlife African American but not white women, adverse associations between abdominal SAT and cardiometabolic risk factors are attenuated and, in the case of subclinical atherosclerosis, are reversed as VAT amounts increase. Given that African American women suffer disproportionately from obesity and cardiovascular disease, further research into the role of this effect modification on obesity-associated vascular disease in African American women is warranted.
有限的数据表明，腹部皮下脂肪组织（SAT）对心血管疾病风险的影响可能取决于腹部内脏脂肪组织（VAT）的伴随量。
本研究旨在探讨腹部 VAT 面积是否会改变腹部 SAT 面积对非裔美国人和白人亚临床动脉粥样硬化和心血管代谢危险因素的影响。
在 500 名中年非裔美国人和白人女性中，通过计算机断层扫描测量腹部 SAT 和 VAT，并与颈动脉内膜中层厚度（cIMT）和心血管代谢危险因素水平相关联。评估了 VAT×SAT 交互项。
样本的平均（±SD）年龄为 51.0±2.9 岁，37%为非裔美国人。SAT 和 VAT 含量越高，cIMT、血压、稳态模型评估胰岛素抵抗指数（HOMA-IR）以及葡萄糖、甘油三酯和胰岛素浓度越高，高密度脂蛋白胆固醇浓度越低。然而，在非裔美国人中，但在白人中，较高的 VAT 量显著减弱了 SAT 量与胰岛素浓度（交互作用 P=0.032）和 HOMA-IR（交互作用 P=0.011）之间的关联，以及与 cIMT（交互作用 P=0.005）和葡萄糖（交互作用 P=0.044）之间的关联。
这些结果表明，在中年非裔美国女性中，但不是在白人女性中，腹部 SAT 与心血管代谢危险因素之间的不良关联减弱，而在亚临床动脉粥样硬化的情况下，随着 VAT 量的增加，这种关联发生逆转。鉴于非裔美国女性不成比例地遭受肥胖和心血管疾病的困扰，进一步研究这种效应修饰在非裔美国女性肥胖相关血管疾病中的作用是有必要的。
