鼻腔上皮样血管内皮瘤

Epithelioid hemangioendothelioma of nasal cavity.

作者信息

Patnayak Rashmi, Jena Amitabh, Reddy M Kumaraswamy, Chowhan Amit Kumar, Rao Lm Chandrasekhar, Rukhamangadha N

机构信息

Department of Pathology, Sri Venketeswar Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.

出版信息

J Lab Physicians. 2010 Jul;2(2):111-3. doi: 10.4103/0974-2727.72214.

DOI:10.4103/0974-2727.72214

PMID:21346909

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3040087/

Abstract

We present a rare case of epithelioid hemangioendothelioma (EHE) in the nasal cavity of a 40-year-old Indian male who presented with history of intermittent epistaxis. The lesion was tested for a panel of immunohistochemical markers like vimentin, CD31, CD34, Factor VIII, vascular endothelial growth factor (VEGF) and Ki67. Immunohistochemically, the neoplasm showed striking positivity for vimentin, CD31, CD34 and weak positivity for VEGF; positivity was also noted for Factor VIII especially in the miniature intracytoplasmic vascular lumina.

摘要

我们报告一例罕见的鼻腔上皮样血管内皮瘤（EHE），患者为一名40岁印度男性，有间歇性鼻出血病史。对该病变进行了一组免疫组化标志物检测，如波形蛋白、CD31、CD34、凝血因子VIII、血管内皮生长因子（VEGF）和Ki67。免疫组化结果显示，肿瘤对波形蛋白、CD31、CD34呈显著阳性，对VEGF呈弱阳性；凝血因子VIII也呈阳性，尤其是在微小的胞质内血管腔中。