Division of Cardiology, Hartford Hospital, Hartford, Connecticut, USA.
Am J Cardiol. 2011 Apr 15;107(8):1246-9. doi: 10.1016/j.amjcard.2010.12.022. Epub 2011 Feb 23.
Low cardiorespiratory fitness and low serum 25-hydroxy vitamin D (25[OH]D) levels are associated with increased cardiovascular and all-cause mortality, but whether low 25(OH)D is independently associated with cardiorespiratory fitness in healthy adults is not known. We examined 25(OH)D levels and fitness in 200 healthy adults participating in a double-blind clinical trial investigating statins and muscle performance (STOMP study). Maximal aerobic exercise capacity (Vo₂(max)) was measured using metabolic gas analysis during graded treadmill exercise to exhaustion. 25(OH)D was measured using an enzyme-linked immunosorbent assay. Daily physical activity was assessed using the Paffenbarger Physical Activity Questionnaire. Serum 25(OH)D concentration was positively related to Vo₂(max) (r = 0.29, p = 0.0001), even after adjusting for relevant predictors (e.g., age, gender, and body mass index). There was also a significant interaction between 25(OH)D level and self-reported hours of moderate to vigorous physical activity (MVPA; p < 0.02). With each SD increase in 25(OH)D, Vo₂(max) increased by 2.6 ml/kg/min (p = 0.0001) when MVPA was low (16 hours/week) and 1.6 ml/kg/min (p <0.0004) when MVPA was moderate (35 hours/week) but only 0.01 ml/kg/min (p = 0.9) when MVPA was high (64 hours/week). In conclusion, serum 25(OH)D levels predict Vo₂(max) in adults; the effect is greatest in those with low levels of physical activity.
低心肺适能和低血清 25-羟维生素 D（25[OH]D）水平与心血管和全因死亡率增加有关，但低 25（OH）D 是否与健康成年人的心肺适能独立相关尚不清楚。我们研究了 200 名参加他汀类药物和肌肉性能双盲临床试验的健康成年人的 25（OH）D 水平和体能（STOMP 研究）。最大有氧运动能力（Vo₂（max））通过代谢气体分析在逐渐增加的跑步机运动至力竭期间进行测量。使用酶联免疫吸附测定法测量 25（OH）D。使用 Paffenbarger 体力活动问卷评估日常体力活动。血清 25（OH）D 浓度与 Vo₂（max）呈正相关（r = 0.29，p = 0.0001），即使在调整了相关预测因素（例如年龄、性别和体重指数）后也是如此。25（OH）D 水平与自我报告的中等到剧烈体力活动（MVPA）时间之间也存在显著的交互作用（p <0.02）。当 MVPA 较低（每周 16 小时）时，25（OH）D 每增加 1 个标准差，Vo₂（max）增加 2.6 ml/kg/min（p = 0.0001），当 MVPA 中等（每周 35 小时）时，Vo₂（max）增加 1.6 ml/kg/min（p <0.0004），但当 MVPA 较高（每周 64 小时）时，Vo₂（max）仅增加 0.01 ml/kg/min（p = 0.9）。总之，血清 25（OH）D 水平可预测成年人的 Vo₂（max）；在体力活动水平较低的人群中，效果最大。
