基于高分辨率探头式共聚焦激光内镜对溃疡性结肠炎中 DALM 的体内特征进行研究。
In-vivo characterization of DALM in ulcerative colitis with high-resolution probe-based confocal laser endomicroscopy.
机构信息
Department of Surgery and Advanced Technologies, Center of Excellence for Technical Innovation in Surgery, Section of Diagnostic and Therapeutic Endoscopy, University of Naples Federico II, School of Medicine, 80131, Naples, Italy.
出版信息
World J Gastroenterol. 2011 Feb 7;17(5):677-80. doi: 10.3748/wjg.v17.i5.677.
Abstract
Recently, the use of confocal laser endomicroscopy (CLE) in the diagnosis of chronic ulcerative colitis (CUC) was reported. In this brief report we aimed to assess the application of probe-based CLE to characterize colonic mucosa and dysplasia in CUC. The study involved a patient presenting long-standing CUC. Confocal imaging of both the inflamed mucosa, a circumscribed lesion (dysplasia-associated lesional mass), and adjacent colonic mucosa are demonstrated and the correlation between the CLE and histological images. Inflamed mucosa and dysplasia showed specific alteration of crypt architecture, cellular infiltration, and vessel architecture with an excellent correlation between CLE and standard histological examination.
摘要
最近，有报道称共聚焦激光内镜检查（CLE）可用于慢性溃疡性结肠炎（CUC）的诊断。在本简要报告中，我们旨在评估基于探头的 CLE 在 CUC 中对结肠黏膜和异型增生进行特征描述的应用。本研究纳入了一位患有长期 CUC 的患者。我们展示了对炎症黏膜、局限性病变（异型增生相关病变团块）和邻近结肠黏膜的共聚焦成像，以及 CLE 与组织学图像之间的相关性。炎症黏膜和异型增生表现出隐窝结构、细胞浸润和血管结构的特定改变，CLE 与标准组织学检查之间具有极好的相关性。
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