Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
J Neurosurg. 2011 Jun;114(6):1693-7. doi: 10.3171/2011.1.JNS10482. Epub 2011 Feb 25.
In patients with medically refractory epilepsy the accurate localization of the seizure onset zone is critical for successful surgical treatment. The object of this study was to investigate whether the degree of coupling of spontaneous brain activity as measured with functional connectivity MR imaging (fcMR imaging) can accurately identify and localize epileptic discharges.
The authors studied 6 patients who underwent fcMR imaging presurgical mapping and subsequently underwent invasive electroencephalography.
Focal regions of statistically significant increases in connectivity were identified in 5 patients when compared with an ad hoc normative sample of 300 controls. The foci identified by fcMR imaging overlapped the epileptogenic areas identified by invasive encephalography in all 5 patients.
These results suggest that fcMR imaging may provide an effective high-spatial resolution and noninvasive method of localizing epileptic discharges in patients with refractory epilepsy.
在药物难治性癫痫患者中，准确定位癫痫发作起始区对于手术治疗的成功至关重要。本研究旨在探讨自发脑活动的耦合程度是否可以通过功能连接磁共振成像（fcMR 成像）准确识别和定位癫痫放电。
作者研究了 6 例接受 fcMR 成像术前定位并随后接受侵袭性脑电图检查的患者。
与 300 例特定的对照样本相比，在 5 例患者中发现了连接性统计学显著增加的焦点。在所有 5 例患者中，fcMR 成像确定的焦点与侵袭性脑电图确定的致痫区重叠。
这些结果表明，fcMR 成像可能为耐药性癫痫患者提供一种有效、高空间分辨率、非侵入性的定位癫痫放电的方法。
