Kruse Astrid L, Luebbers Heinz T, Grätz Klaus W
University Hospital Zurich, Department of Craniomaxillofacial and Oral Surgery, Zurich/Switzerland.
Head Neck Oncol. 2011 Feb 27;3:13. doi: 10.1186/1758-3284-3-13.
There seems to be increasing evidence that inflammation leads to cancer. For several cancers, an association with white blood cell (WBC) count has been reported. So far, no studies have been performed for cancer of the oral cavity and WBC. Therefore, the aim of the present study was to look at whether WBC count can be used as a prognostic marker for recurrence or metastases for oral cancer.
For 278 patients with oral cancer, the preoperative WBC count was compared with the clinicopathological information: age, gender, T-status, N-status, recurrence, metastases, follow-up time, and time till recurrence or metastases appeared.
Out of 278 patients, 48 developed recurrence, 24 second tumors, 46 cervical metastases, and 14 distant metastases. The mean follow-up time was 35.97 months (range: 12-107 months). Significant Pearson correlation at the 0.05 level could be found for the T-status (0.046), but not for the N status (0.121). No significant correlation could be found between WBC count and the development of recurrence or metastases.
In conclusion, our findings demonstrate that elevated WBC count does not seem to be a predictor for recurrence or for further metastases. Further research is recommended to investigate the WBC count in precancerous lesions and in HPV positive patients with oral SCC.
越来越多的证据表明炎症会引发癌症。对于几种癌症，已有报告称其与白细胞（WBC）计数有关。迄今为止，尚未针对口腔癌与白细胞进行相关研究。因此，本研究的目的是探讨白细胞计数是否可作为口腔癌复发或转移的预后标志物。
对278例口腔癌患者，将术前白细胞计数与临床病理信息进行比较，这些信息包括年龄、性别、T分期、N分期、复发情况、转移情况、随访时间以及出现复发或转移的时间。
278例患者中，48例出现复发，24例出现第二原发肿瘤，46例出现颈部转移，14例出现远处转移。平均随访时间为35.97个月（范围：12 - 107个月）。在0.05水平上，T分期有显著的皮尔逊相关性（0.046），而N分期无显著相关性（0.121）。白细胞计数与复发或转移的发生之间未发现显著相关性。
总之，我们的研究结果表明白细胞计数升高似乎并非复发或进一步转移的预测指标。建议进一步研究癌前病变以及HPV阳性的口腔鳞状细胞癌患者的白细胞计数情况。
