Zhang Wei, Moore Lynette, Ji Ping
Chin J Cancer. 2011 Mar;30(3):149-52. doi: 10.5732/cjc.011.10047.
Mouse models of cancer enable researchers to learn about tumor biology in complicated and dynamic physiological systems. Since the development of gene targeting in mice, cancer biologists have been among the most frequent users of transgenic mouse models, which have dramatically increased knowledge about how cancers form and grow. The Chinese Journal of Cancer will publish a series of papers reporting the use of mouse models in studying genetic events in cancer cases. This editorial is an overview of the development and applications of mouse models of cancer and directs the reader to upcoming papers describing the use of these models to be published in coming issues, beginning with three articles in the current issue.
癌症小鼠模型使研究人员能够在复杂且动态的生理系统中了解肿瘤生物学。自从小鼠基因靶向技术发展以来，癌症生物学家一直是转基因小鼠模型的最频繁使用者，这些模型极大地增加了我们对癌症如何形成和生长的认识。《中国癌症杂志》将发表一系列论文，报道小鼠模型在研究癌症病例中的遗传事件方面的应用。这篇社论概述了癌症小鼠模型的发展和应用，并引导读者关注即将在后续期刊上发表的描述这些模型应用的论文，本期就有三篇相关文章开篇。
