用于癌症研究的小鼠模型。
Mouse models for cancer research.
作者信息
Zhang Wei, Moore Lynette, Ji Ping
出版信息
Chin J Cancer. 2011 Mar;30(3):149-52. doi: 10.5732/cjc.011.10047.
Abstract
Mouse models of cancer enable researchers to learn about tumor biology in complicated and dynamic physiological systems. Since the development of gene targeting in mice, cancer biologists have been among the most frequent users of transgenic mouse models, which have dramatically increased knowledge about how cancers form and grow. The Chinese Journal of Cancer will publish a series of papers reporting the use of mouse models in studying genetic events in cancer cases. This editorial is an overview of the development and applications of mouse models of cancer and directs the reader to upcoming papers describing the use of these models to be published in coming issues, beginning with three articles in the current issue.
摘要
癌症小鼠模型使研究人员能够在复杂且动态的生理系统中了解肿瘤生物学。自从小鼠基因靶向技术发展以来，癌症生物学家一直是转基因小鼠模型的最频繁使用者，这些模型极大地增加了我们对癌症如何形成和生长的认识。《中国癌症杂志》将发表一系列论文，报道小鼠模型在研究癌症病例中的遗传事件方面的应用。这篇社论概述了癌症小鼠模型的发展和应用，并引导读者关注即将在后续期刊上发表的描述这些模型应用的论文，本期就有三篇相关文章开篇。
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本文引用的文献
1
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J Natl Cancer Inst. 2010 Nov 17;102(22):1694-7. doi: 10.1093/jnci/djq480. Epub 2010 Nov 8.
2
Mouse models of cancer.癌症的小鼠模型。
Annu Rev Pathol. 2011;6:95-119. doi: 10.1146/annurev.pathol.3.121806.154244.
3
Modeling metastasis in the mouse.在小鼠中建立转移模型。
Curr Opin Pharmacol. 2010 Oct;10(5):571-7. doi: 10.1016/j.coph.2010.06.003. Epub 2010 Jul 1.
4
Genetically engineered mouse models in cancer research.癌症研究中的基因工程小鼠模型。
Adv Cancer Res. 2010;106:113-64. doi: 10.1016/S0065-230X(10)06004-5.
5
New approaches for modelling sporadic genetic disease in the mouse.新型方法用于在小鼠中模拟散发性遗传病。
Dis Model Mech. 2009 Sep-Oct;2(9-10):446-53. doi: 10.1242/dmm.001644.
6
Tissue-specific and reversible RNA interference in transgenic mice.转基因小鼠中的组织特异性和可逆RNA干扰
Nat Genet. 2007 Jul;39(7):914-21. doi: 10.1038/ng2045. Epub 2007 Jun 17.
7
Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function.p53的靶向点突变导致野生型p53功能的显性负性抑制。
Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2948-53. doi: 10.1073/pnas.052713099. Epub 2002 Feb 26.
8
Engineering chromosomal rearrangements in mice.在小鼠中构建染色体重排
Nat Rev Genet. 2001 Oct;2(10):780-90. doi: 10.1038/35093564.
9
Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice.碱性成纤维细胞生长因子在小鼠进行胶质细胞特异性基因转移后可诱导细胞迁移和增殖。
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10
Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes.携带并表达MTV/ myc融合基因的转基因小鼠中的自发性乳腺腺癌。
Cell. 1984 Oct;38(3):627-37. doi: 10.1016/0092-8674(84)90257-5.
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