UCD Centre for Human Reproduction, Coombe Women and Infants University Hospital, Dublin, Ireland.
Eur J Obstet Gynecol Reprod Biol. 2011 Jul;157(1):14-7. doi: 10.1016/j.ejogrb.2010.12.047. Epub 2011 Feb 25.
To identify the maternal body composition parameters that independently influence birth weight.
A longitudinal prospective observational study in a large university teaching hospital. One hundred and eighty-four non-diabetic caucasian women with a singleton pregnancy were studied. In early pregnancy maternal weight and height were measured digitally in a standardised way and the body mass index (BMI) was calculated. At 28 and 37 weeks' gestation maternal body composition was assessed using segmental multifrequency bioelectrical impedance analysis. At delivery the baby was weighed and the clinical details were recorded.
Of the women studied, 29.2% were overweight and 34.8% were obese. Birth weight did not correlate with maternal weight or BMI in early pregnancy. Birth weight correlated with gestational weight gain (GWG) before the third trimester (r=0.163, p=0.027), but not with GWG in the third trimester. Birth weight correlated with maternal fat-free mass, and not fat mass at 28 and 37 weeks gestation. Birth weight did not correlate with increases in maternal fat and fat-free masses between 28 and 37 weeks.
Contrary to previous reports, we found that early pregnancy maternal BMI in a non-diabetic population does not influence birth weight. Interestingly, it was the GWG before the third trimester and not the GWG in the third trimester that influenced birth weight. Our findings have implications for the design of future intervention studies aimed at optimising gestational weight gain and birth weight.
Maternal fat-free mass and gestational weight gain both influence birth weight.
确定独立影响出生体重的母体成分参数。
在一所大型大学教学医院进行的纵向前瞻性观察研究。研究了 184 名非糖尿病的白种人单胎妊娠妇女。在孕早期，以标准化方式数字测量了母亲的体重和身高，并计算了体重指数（BMI）。在 28 周和 37 周妊娠时，使用分段多频生物电阻抗分析评估了母体身体成分。分娩时，对婴儿进行称重并记录临床细节。
在所研究的妇女中，29.2%超重，34.8%肥胖。出生体重与孕早期母亲体重或 BMI 不相关。出生体重与孕晚期前的体重增加（GWG）相关（r=0.163，p=0.027），但与孕晚期的 GWG 不相关。出生体重与母亲在 28 周和 37 周时的无脂肪质量相关，而与脂肪质量无关。出生体重与 28 至 37 周期间母亲脂肪和无脂肪质量的增加无关。
与之前的报告相反，我们发现非糖尿病人群中孕早期的母亲 BMI 并不影响出生体重。有趣的是，影响出生体重的是孕晚期前的 GWG，而不是孕晚期的 GWG。我们的研究结果对未来旨在优化孕晚期 GWG 和出生体重的干预研究设计具有重要意义。
母亲的无脂肪质量和孕晚期体重增加都会影响出生体重。
