超声对氟喹诺酮类抗菌活性的影响。
The influence of ultrasound on the fluoroquinolones antibacterial activity.
机构信息
Department of Pharmacy, Liaoning University, Shenyang, PR China.
出版信息
Ultrason Sonochem. 2011 Sep;18(5):1052-6. doi: 10.1016/j.ultsonch.2011.02.001. Epub 2011 Feb 15.
In this work, the antibacterial effect of fluoroquinolones (FQs) upon Escherichia coli (E.coli) was measured with and without application of 40 kHz ultrasound (US) stimulation. The research results demonstrated that simultaneous application of 40 kHz US apparently enhanced the antibacterial effectiveness of FQs. That is, the synergistic effect was observed and the bacterial viability was reduced when FQs and US were combined. In addition, various influencing factors, such as FQs drug concentration, US irradiation time and solution temperature, on the inhibition of E.coli were also investigated. The antibacterial activity was enhanced apparently with increasing of FQs drug concentration, US irradiation time and solution temperature. Furthermore, we discussed preliminarily the mechanism of US enhanced antibacterial activity. Results show that US can activate FQs to produce reactive oxygen species (ROS) indeed, which are mainly determined as superoxide radical anion (·O(2)(-)) and hydroxyl radical (·OH).
在这项工作中，测量了氟喹诺酮类药物（FQs）在应用 40 kHz 超声（US）刺激前后对大肠杆菌（E.coli）的抗菌效果。研究结果表明，同时应用 40 kHz US 明显增强了 FQs 的抗菌效果。也就是说，当 FQs 和 US 联合使用时，观察到协同作用，细菌活力降低。此外，还研究了各种影响因素，如 FQs 药物浓度、US 辐照时间和溶液温度，对 E.coli 的抑制作用。随着 FQs 药物浓度、US 辐照时间和溶液温度的增加，抗菌活性明显增强。此外，我们初步探讨了 US 增强抗菌活性的机制。结果表明，US 确实可以激活 FQs 产生活性氧（ROS），主要为超氧阴离子自由基（·O(2)(-))和羟基自由基（·OH）。
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