Department of Neurology University of Copenhagen, Rigshospitalet, Denmark.
Trials. 2011 Feb 28;12:55. doi: 10.1186/1745-6215-12-55.
The effect of pregabalin on acute herpes zoster pain has not been previously evaluated.
In a randomized, double-blind, placebo-controlled, two-session crossover study the effect of a single oral dose of pregabalin (150 mg) on pain and allodynia was evaluated in 8 subjects with herpes zoster.
Over 6 hours of observation, pain decreased by a mean of 33% with pregabalin and 14% with placebo (p < 0.10). Effects on allodynia and SF-MPQ were not significant.
Compared to an earlier study of gabapentin 900 mg for acute zoster pain and allodynia that followed a nearly identical protocol, pregabalin had a similar effect on pain and was well tolerated, with no difference from placebo on sleepiness. Common side effects of light-headedness, unsteady gait, and slowed thinking were almost identical to that observed in the earlier study of gabapentin. Subject recruitment proved difficult in part due to the widespread off-label use of gabapentin and pregabalin for acute zoster pain in our region of the USA.
ClinicalTrials.gov Identifier: NCT00352651.
普瑞巴林对急性带状疱疹疼痛的影响尚未得到评估。
在一项随机、双盲、安慰剂对照、两周期交叉研究中，评估了单剂量口服普瑞巴林（150 毫克）对 8 例带状疱疹患者疼痛和感觉异常的影响。
在 6 小时的观察中，普瑞巴林组疼痛减轻了 33%，安慰剂组减轻了 14%（p<0.10）。对感觉异常和 SF-MPQ 的影响不显著。
与遵循几乎相同方案的早期关于加巴喷丁 900 毫克治疗急性带状疱疹疼痛和感觉异常的研究相比，普瑞巴林对疼痛的作用相似，且耐受性良好，与安慰剂相比，嗜睡无差异。头晕、步态不稳和思维迟钝等常见副作用与加巴喷丁早期研究中观察到的几乎相同。由于在美国我们所在地区普瑞巴林和加巴喷丁被广泛超适应证用于治疗急性带状疱疹疼痛，部分导致了受试者招募困难。
ClinicalTrials.gov 标识符：NCT00352651。
