眼前房作为临床移植部位治疗糖尿病：在糖尿病狒狒模型中的研究。
The anterior chamber of the eye as a clinical transplantation site for the treatment of diabetes: a study in a baboon model of diabetes.
机构信息
Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
出版信息
Diabetologia. 2011 May;54(5):1121-6. doi: 10.1007/s00125-011-2091-y. Epub 2011 Mar 1.
Abstract
AIMS/HYPOTHESIS: The aim of this study was to provide evidence that the anterior chamber of the eye serves as a novel clinical islet implantation site.
METHODS
In a preclinical model, allogeneic pancreatic islets were transplanted into the anterior chamber of the eye of a baboon model for diabetes, and metabolic and ophthalmological outcomes were assessed.
RESULTS
Islets readily engrafted on the iris and there was a decrease in exogenous insulin requirements due to insulin secretion from the intraocular grafts. No major adverse effects on eye structure and function could be observed during the transplantation period.
CONCLUSIONS/INTERPRETATION: Our study demonstrates the long-term survival and function of allogeneic islets after transplantation into the anterior chamber of the eye. The safety and simplicity of this procedure provides support for further studies aimed at translating this technology into the clinic.
摘要
目的/假设：本研究旨在提供证据表明眼球前房是一个新的临床胰岛移植部位。
方法
在临床前模型中，将同种异体胰岛移植到糖尿病狒狒模型的眼前房，评估代谢和眼科结果。
结果
胰岛容易在虹膜上移植，并且由于眼内移植物的胰岛素分泌，外源性胰岛素的需求减少。在移植期间，未观察到对眼睛结构和功能的重大不良影响。
结论/解释：我们的研究表明，同种异体胰岛移植到眼前房后可以长期存活和发挥功能。该手术的安全性和简单性为进一步研究将该技术转化为临床应用提供了支持。
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本文引用的文献
1
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Diabetes. 2009 Oct;58(10):2175-84. doi: 10.2337/db09-0476.
2
Long-term survival of nonhuman primate islets implanted in an omental pouch on a biodegradable scaffold.植入可生物降解支架网膜袋内的非人灵长类动物胰岛的长期存活。
Am J Transplant. 2009 Jan;9(1):91-104. doi: 10.1111/j.1600-6143.2008.02489.x.
3
Noninvasive high-resolution in vivo imaging of cell biology in the anterior chamber of the mouse eye.小鼠眼前房中细胞生物学的无创高分辨率体内成像。
Nat Protoc. 2008;3(8):1278-86. doi: 10.1038/nprot.2008.118.
4
Noninvasive in vivo imaging of pancreatic islet cell biology.胰岛细胞生物学的无创体内成像
Nat Med. 2008 May;14(5):574-8. doi: 10.1038/nm1701. Epub 2008 Mar 7.
5
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Diabetologia. 2008 Feb;51(2):227-32. doi: 10.1007/s00125-007-0868-9. Epub 2007 Nov 27.
6
Interference with tissue factor prolongs intrahepatic islet allograft survival in a nonhuman primate marginal mass model.在非人灵长类边缘性胰岛移植模型中，干扰组织因子可延长肝内胰岛移植的存活时间。
Transplantation. 2007 Aug 15;84(3):308-15. doi: 10.1097/01.tp.0000275401.80187.1e.
7
The induction of anterior chamber-associated immune deviation.前房相关免疫偏离的诱导。
Chem Immunol Allergy. 2007;92:27-35. doi: 10.1159/000099251.
8
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N Engl J Med. 2006 Sep 28;355(13):1318-30. doi: 10.1056/NEJMoa061267.
9
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10
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