提高非线性拉曼微光谱成像和传感的灵敏度。
Improving sensitivity in nonlinear Raman microspectroscopy imaging and sensing.
机构信息
University of Wisconsin - Milwaukee, Department of Physics, 1900 E. Kenwood Boulevard, Milwaukee, Wisconsin 53211, USA.
出版信息
J Biomed Opt. 2011 Feb;16(2):021114. doi: 10.1117/1.3533317.
Abstract
Nonlinear Raman microspectroscopy based on a broadband coherent anti-Stokes Raman scattering is an emerging technique for noninvasive, chemically specific, microscopic analysis of tissues and large population of cells and particles. The sensitivity of this imaging is a critical aspect of a number of the proposed biomedical application. It is shown that the incident laser power is the major parameter controlling this sensitivity. By careful optimizing the laser system, the high-quality vibrational spectra acquisition at the multi-kHz rate becomes feasible.
摘要
基于宽带相干反斯托克斯拉曼散射的非线性拉曼微光谱技术是一种新兴的技术，可用于非侵入式、化学特异性、组织和大量细胞和颗粒的微观分析。该成像技术的灵敏度是许多拟议的生物医学应用的关键方面。结果表明，入射激光功率是控制这种灵敏度的主要参数。通过仔细优化激光系统，以多千赫速率获取高质量的振动光谱成为可能。
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