Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul.
Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea.
Chest. 2011 Mar;139(3):687-690. doi: 10.1378/chest.10-1558.
Propylthiouracil (PTU) is a drug used to treat hyperthyroidism. A number of adverse effects have been reported with this drug, including fever, agranulocytosis, skin rash, and vasculitis. PTU-induced interstitial pneumonia is rare--only three cases have been reported--and PTU-induced nonspecific interstitial pneumonia (NSIP) has not been reported. We report a patient who developed NSIP after taking PTU for 1 year. She developed dyspnea, cough, and mild fever lasting 1 month, and a chest CT scan showed multifocal patchy consolidation in both lungs. She underwent a surgical lung biopsy, and NSIP was confirmed pathologically. The symptoms and abnormalities seen in the chest radiograph improved after withdrawal of PTU. To our knowledge, this is the first documented case of pathologically proven PTU-induced NSIP.
丙硫氧嘧啶（PTU）是一种用于治疗甲状腺功能亢进的药物。该药物有许多不良反应的报道，包括发热、粒细胞缺乏症、皮疹和血管炎。PTU 引起的间质性肺炎很少见，仅有三例报告，PTU 引起的非特异性间质性肺炎（NSIP）尚未报告。我们报告了一例患者在服用 PTU 1 年后发生 NSIP。她出现呼吸困难、咳嗽和持续 1 个月的轻度发热，胸部 CT 扫描显示双肺多灶性斑片状实变。她接受了外科肺活检，病理证实为 NSIP。停用 PTU 后，患者的症状和胸部 X 线异常均得到改善。据我们所知，这是首例经病理证实的 PTU 诱导的 NSIP 病例。
