National Institute of Public Health and the Environment (RIVM), Centre for Infectious Disease Control Netherlands, P.O. Box 1, 3720, BA Bilthoven, The Netherlands.
Eur J Clin Microbiol Infect Dis. 2011 Jul;30(7):873-9. doi: 10.1007/s10096-011-1170-9. Epub 2011 Mar 2.
Toxocara canis, Toxocara cati and Ascaris suum are roundworms of dogs, cats and pigs, respectively, that can also infect humans. These zoonotic helminths have a worldwide distribution and are also endemic in the Netherlands. Infection with Toxocara sp. may result in visceral larva migrans (VLM) or ocular larva migrans (OLM) caused by the migrating larvae. Although A. suum has been reported to occasionally mature to the adult stage in humans, clinical cases of VLM suspected to be caused by A. suum have been described. Diagnosis of these helminth infections relies mainly on serology. Here we analyse the results from the Toxocara and Ascaris IgG-ELISA from a total of 2,838 serum samples from VLM and OLM suspected patients that were sent to our institution from 1998 to 2009. Results indicate that for each year the Ascaris seropositivity is significantly higher compared to the Toxocara seropositivity. Furthermore, while Toxocara seropositivity has decreased over time, the Ascaris seropositivity has not significantly changed for the past 12 years. The Ascaris and Toxocara seropositivity was also shown to increases with age and, while gender has no influence on the Ascaris seropositivity, males showed higher Toxocara seropositivity.
犬弓首蛔虫、猫弓首蛔虫和猪蛔虫分别是犬、猫和猪的圆形线虫，也可感染人类。这些人畜共患的蠕虫在全世界范围内分布，并在荷兰流行。感染弓首蛔虫属可导致内脏幼虫移行症（VLM）或眼幼虫移行症（OLM），由移行幼虫引起。虽然有报道称猪蛔虫偶尔会在人体内成熟为成虫，但已描述了疑似由猪蛔虫引起的 VLM 临床病例。这些寄生虫感染的诊断主要依赖于血清学。在这里，我们分析了 1998 年至 2009 年期间，我院共收到的 2838 份疑似 VLM 和 OLM 患者血清样本的 Toxocara 和 Ascaris IgG-ELISA 结果。结果表明，每年的蛔虫血清阳性率明显高于弓首蛔虫血清阳性率。此外，虽然弓首蛔虫血清阳性率随时间推移而降低，但在过去 12 年中，蛔虫血清阳性率并未显著变化。蛔虫和弓首蛔虫的血清阳性率也随着年龄的增长而增加，而性别对蛔虫血清阳性率没有影响，但男性的弓首蛔虫血清阳性率更高。
