Zinad Dhafer Saber, Shaaban Khaled A, Abdalla Muna Ali, Islam Md Tofazzal, Schüffler Anja, Laatsch Hartmut
Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
Nat Prod Commun. 2011 Jan;6(1):45-8.
Four isocoumarins have been isolated from the terrestrial Streptomyces sp. ANK302, namely 6,8-dimethoxy-3-methylisocoumarin (1), 6,8-dihydroxy-3-methylisocoumarin (2), 6,8-dihydroxy-7-methoxy-3-methylisocoumarin (3), and 6,7,8-trimethoxy-3-methylisocoumarin (4). Compound 1 is a new naturally-occurring isocoumarin, and 2 was isolated as a new bacterial product. The structures 1-4 were deduced from high resolution mass, 1D and 2D NMR spectra and by comparison with related compounds from the literature. Compound 2 showed a strong zoosporicidal activity at a concentration of 5 microg/mL against a phytopathogenic oomycete, Plasmopara viticola, and 1 was active against
已从陆生链霉菌属菌株ANK302中分离出四种异香豆素，即6,8-二甲氧基-3-甲基异香豆素（1）、6,8-二羟基-3-甲基异香豆素（2）、6,8-二羟基-7-甲氧基-3-甲基异香豆素（3）和6,7,8-三甲氧基-3-甲基异香豆素（4）。化合物1是一种新的天然存在的异香豆素，化合物2作为一种新的细菌产物被分离出来。通过高分辨率质谱、一维和二维核磁共振光谱并与文献中的相关化合物进行比较，推断出化合物1-4的结构。化合物2在浓度为5微克/毫升时对植物致病卵菌葡萄生单轴霉表现出很强的杀游动孢子活性，化合物1对……有活性
