Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530000, China.
Mar Drugs. 2023 Feb 25;21(3):150. doi: 10.3390/md21030150.
Five new isocoumarins, phaeosphaerins A-E (-), were isolated from the fermentation broth of the marine fungus sp. WP-26, along with one known isocoumarin, 6,8-dihydroxy-7-methoxy-3-methylisocoumarin (), and two known pimarane-type diterpenes, diaportheins A () and B (). Their structures were elucidated via NMR experiments, X-ray diffraction analysis, and comparison of the experimental and computed ECD curves. Compounds - displayed weak neuroprotective effects against HO-induced damage in SH-SY5Y cells. Moreover, compound showed cytotoxicity against BEL-7402, SGC-7901, K562, A549, and HL-60 cell lines.
从海洋真菌 sp. WP-26 的发酵液中分离得到了五个新的异香豆素化合物，分别为 phaeosphaerins A-E（-），此外还有一个已知的异香豆素化合物 6,8-二羟基-7-甲氧基-3-甲基异香豆素（），以及两个已知的海松烷型二萜 diaportheins A（）和 B（）。通过 NMR 实验、X 射线衍射分析和实验与计算的 ECD 曲线比较，确定了它们的结构。化合物 - 对 HO 诱导的 SH-SY5Y 细胞损伤表现出较弱的神经保护作用。此外，化合物 对 BEL-7402、SGC-7901、K562、A549 和 HL-60 细胞系表现出细胞毒性。
