Department of Oncology and Radiotherapy, Medical University of Gdańsk, 7 Dębinki St., 80-211, Gdańsk, Poland.
Arch Gynecol Obstet. 2011 Mar;283 Suppl 1(Suppl 1):97-100. doi: 10.1007/s00404-011-1855-4. Epub 2011 Mar 3.
The safety of chemotherapy during pregnancy is debatable. We present a case of advanced ovarian cancer, diagnosed at week 28 of gestational age, treated with 2 cycles of paclitaxel/cisplatin (TC) chemotherapy during pregnancy, with no serious toxicity. At week 34, the patient underwent a caesarean section and delivered a healthy girl. Four additional cycles of TC were administered. Three months after completing chemotherapy, the patient developed abdominal progression and subsequently a huge metastatic cystic mass in the brain. Despite subsequent therapies, the patient died of progressive disease 35 months after the diagnosis. The infant had normal growth and development by 73 months of her age. This is another reported case of ovarian cancer diagnosed during the second trimester of the pregnancy treated with TC chemotherapy without apparent teratogenic effect.
化疗在妊娠期的安全性存在争议。我们报告了 1 例在妊娠 28 周时诊断为晚期卵巢癌的病例，该患者在妊娠期接受了 2 个周期的紫杉醇/顺铂（TC）化疗，没有出现严重的毒性反应。在 34 周时，患者行剖宫产术并娩出 1 名健康女婴。随后又进行了 4 个周期的 TC 化疗。化疗结束 3 个月后，患者出现腹部进展，并随后在大脑中出现巨大的转移性囊性肿块。尽管随后进行了治疗，但患者在诊断后 35 个月死于疾病进展。婴儿在 73 个月时生长发育正常。这是另 1 例在妊娠中期诊断为卵巢癌的病例，该患者接受 TC 化疗治疗，未出现明显的致畸作用。
