Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Taastrup, Denmark.
Vet J. 2012 Feb;191(2):199-202. doi: 10.1016/j.tvjl.2011.01.019. Epub 2011 Mar 2.
European and American guidelines for vaccination against tetanus and influenza in horses recommend annual and annual/semi-annual vaccinations, respectively, against the two pathogens. Too-frequent vaccination may, however, have adverse effects, among other things because an inflammatory response is elicited with subsequent alterations in homeostasis. The objective of the study was to compare the acute phase response (APR) in 10 horses following administration of two different types of vaccines, namely, an inactivated Immune Stimulating COMplex (ISCOM) vaccine and a live recombinant vector vaccine. Blood was sampled before and after vaccination to measure levels of serum amyloid A (SAA), fibrinogen, white blood cell counts (WBC) and iron. Vaccination induced a prominent APR with increased WBC, elevated blood levels of SAA and fibrinogen, and decreased serum iron concentrations. The ISCOM vaccine caused significantly (P<0.05) greater SAA, fibrinogen and WBC responses than the vector vaccine. During the APR muscle catabolism and liver and kidney metabolism are altered. Also drug metabolism may change during the APR. The findings of the present study may be relevant for advising horse owners about convalescence after vaccination.
欧美针对马破伤风和流感的疫苗接种指南建议针对这两种病原体分别进行每年和每年/半年一次的接种。然而，过于频繁的接种可能会产生不良影响，其中包括引发炎症反应，从而导致体内平衡发生改变。本研究的目的是比较 10 匹马在接种两种不同类型疫苗（即灭活免疫刺激复合物（ISCOM）疫苗和活重组载体疫苗）后的急性期反应（APR）。在接种前后采集血液样本，以测量血清淀粉样蛋白 A（SAA）、纤维蛋白原、白细胞计数（WBC）和铁的水平。接种会引起明显的 APR，导致 WBC 增加、SAA 和纤维蛋白原血液水平升高以及血清铁浓度降低。ISCOM 疫苗引起的 SAA、纤维蛋白原和 WBC 反应明显（P<0.05）高于载体疫苗。APR 期间肌肉分解代谢以及肝肾功能代谢会发生改变。此外，药物代谢也可能在 APR 期间发生变化。本研究的结果可能与为马主提供接种后恢复期的建议有关。
