Shinozaki Masae, Kanazawa Motoyori, Palsson Olafur S, Sagami Yasuhiro, Endo Yuka, Hongo Michio, Drossman Douglas A, Whitehead William E, Fukudo Shin
Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Japan.
Intern Med. 2011;50(5):375-80. doi: 10.2169/internalmedicine.50.4589. Epub 2011 Mar 1.
The comorbid conditions questionnaire (CCQ) and the recent physical symptoms questionnaire (RPSQ) have been validated in the US for the evaluation of comorbid physical conditions in patients with irritable bowel syndrome (IBS). A lack of instruments to assess somatization in Japanese subjects with IBS warrants development of the Japanese versions of these questionnaires. The purpose of this study was to validate the Japanese versions created, the CCQ-J and RPSQ-J.
Study 1 was carried out to verify the test-retest reliability and internal consistency of the CCQ-J and RPSQ-J in 49 patients with functional bowel disorder. Study 2 was performed to confirm the construct validities of these questionnaires compared to the Cornell Medical Index (CMI) in 120 patients with psychosomatic symptoms (assigned to the somatoform disorder, anxiety disorder, depressive disorder, or IBS group) and 22 healthy subjects.
In Study 1, high reproducibility and high intraclass correlation coefficients were demonstrated for these questionnaires. In Study 2, total score on the CMI was significantly associated with score on the CCQ-J and on the RPSQ-J in the IBS group. The proportion of patients with chronic back pain was significantly higher in the IBS group than in controls (27.3% vs. 18.5%, p<0.05).
The CCQ-J and RPSQ-J are valid and reliable instruments for evaluating comorbid conditions in Japanese patients with IBS. Further studies are needed to confirm the direct cross-cultural comparison of the impact of somatization in IBS between different countries.
共病情况问卷（CCQ）和近期身体症状问卷（RPSQ）在美国已得到验证，用于评估肠易激综合征（IBS）患者的共病身体状况。由于缺乏评估日本IBS患者躯体化的工具，因此需要开发这些问卷的日语版本。本研究的目的是验证所创建的日语版本，即CCQ-J和RPSQ-J的有效性。
研究1旨在验证CCQ-J和RPSQ-J在49例功能性肠病患者中的重测信度和内部一致性。研究2在120例有身心症状的患者（分为躯体形式障碍、焦虑症、抑郁症或IBS组）和22名健康受试者中进行，以确认这些问卷与康奈尔医学指数（CMI）相比的结构效度。
在研究1中，这些问卷显示出高重现性和高组内相关系数。在研究2中，IBS组中CMI的总分与CCQ-J和RPSQ-J的得分显著相关。IBS组慢性背痛患者的比例显著高于对照组（27.3%对18.5%，p<0.05）。
CCQ-J和RPSQ-J是评估日本IBS患者共病情况的有效且可靠的工具。需要进一步研究以确认不同国家间IBS患者躯体化影响的直接跨文化比较。
