Feng Xiaolu, Lu Jincai, Xin Hailiang, Zhang Lei, Wang Yuliang, Tang Kexuan
Plant Biotechnology Research Center, School of Agriculture and Biology, Fudan-SJTU-Nottingham Plant Biotechnology R&D Center, Shanghai Jiao Tong University, China.
Yakugaku Zasshi. 2011 Mar;131(3):423-9. doi: 10.1248/yakushi.131.423.
The aim of this study was to ascertain the anti-arthritic active fraction of Capparis spinosa L. (Capparidaceae) fruits and its chemical constituents. The adjuvant arthritic rat model was developed to evaluate the anti-arthritic effects of different fractions of ethanol extraction from C. spinosa L. The fraction eluted by ethanol-water (50:50, v/v) had the most significant anti-arthritic activity. The chemical constituents of this fraction were therefore studied; seven known compounds were isolated and identified as: P-hydroxy benzoic acid; 5-(hydroxymethyl) furfural; bis(5-formylfurfuryl) ether; daucosterol; α-D-fructofuranosides methyl; uracil; and stachydrine.
本研究的目的是确定刺山柑（白花菜科）果实的抗关节炎活性成分及其化学成分。建立佐剂性关节炎大鼠模型以评估刺山柑乙醇提取物不同馏分的抗关节炎作用。用乙醇 - 水（50:50，v/v）洗脱的馏分具有最显著的抗关节炎活性。因此对该馏分的化学成分进行了研究；分离并鉴定出七种已知化合物，分别为：对羟基苯甲酸；5 -（羟甲基）糠醛；双（5 - 甲酰基糠基）醚；胡萝卜苷；α - D - 呋喃果糖苷甲酯；尿嘧啶；以及水苏碱。
