Qazvin Blood Transfusion Centre, Iran Blood Transfusion Organisation Research Centre, PO Box 34166-13445, Qazvin, Iran.
Singapore Med J. 2011 Feb;52(2):107-12.
The hepatitis A virus (HAV) is a major global health problem, especially in developing countries. Although children aged 5-14 years are the most infected age group, all age groups are equally affected in an HAV epidemic. The aim of this study was to determine the prevalence and related risk factors of HAV among blood donors in Qazvin, central Iran.
A cross-sectional study was performed in April 2008 on a total of 351 blood donors aged 17 to 60 years. Information on demographic variables and probable risk factors was recorded. The blood samples were investigated for antibodies to HAV (HAV Ab). Data was analysed using the t-test, chi-square test and Fisher's exact test to examine the factors related to HAV Ab positivity.
Out of the 351 blood donors, 49.0 percent (n is 172) were regular blood donors, 94.0 percent (n is 330) were male and 71.0 percent (n is 248) were married. HAV Ab was found in 94.9 percent (n is 333) of the total sample. The prevalence of HAV Ab was higher among married and older participants. It was lower among those with a high school or vocational level of education (p is less than 0.05) than among those with a lower level of education.
This study reveals a high prevalence of HAV Ab among adult blood donors in Qazvin, which indicates a high level of childhood contact with HAV in the area.
甲型肝炎病毒（HAV）是一个全球性的健康问题，尤其是在发展中国家。尽管 5-14 岁的儿童是最易感染的年龄组，但在甲型肝炎病毒流行期间，所有年龄组都同样受到影响。本研究旨在确定伊朗中部卡兹温市献血者中 HAV 的流行率及相关危险因素。
2008 年 4 月，对 351 名年龄在 17 至 60 岁的献血者进行了横断面研究。记录了人口统计学变量和可能的危险因素信息。对血液样本进行了甲型肝炎病毒抗体（HAV Ab）检测。采用 t 检验、卡方检验和 Fisher 精确检验分析数据，以检查与 HAV Ab 阳性相关的因素。
在 351 名献血者中，49.0%（n=172）为定期献血者，94.0%（n=330）为男性，71.0%（n=248）为已婚。总样本中 HAV Ab 的检出率为 94.9%（n=333）。已婚和年龄较大的参与者中 HAV Ab 的患病率较高。与受教育程度较低的人相比，具有高中或职业教育水平的人（p 小于 0.05）HAV Ab 的患病率较低。
本研究表明，卡兹温市成年献血者中 HAV Ab 的流行率较高，这表明该地区儿童接触 HAV 的水平较高。
