Ege University, Medical Faculty, Department of Pediatrics, 35100 Izmir, Turkey.
Vaccine. 2011 Aug 26;29(37):6259-61. doi: 10.1016/j.vaccine.2011.06.069. Epub 2011 Jul 18.
The seroprevalence study was conducted in order to determine the current seroepidemiology hepatitis A in Izmir, Turkey and to evaluate the epidemiological shift in HAV serostatus. Blood samples collected from 595 subjects aged 1-60 years were analyzed for anti-HAV IgG antibodies. The current study results were compared with those of a previous study conducted in 1998 involving the same location. There was a marked decrease in the prevalence of anti-HAV between 1998 and 2008. While anti-HAV seroprevalence rates in the current study were 4.6% in children aged 1-4 years, 23% in children aged 10-14 years, and 85% in young adults aged 20-29 years, the prevalence rates were 36% in the 1-4 years age group, 65% in the 10-14 years age group, and 95% in young adults in the previous study, indicating a shift in HAV seroprevalence from the younger to the higher age groups. As HAV infection in childhood is decreasing, the pool of susceptible adolescents and young adults is increasing in Izmir, Turkey. The majority of adolescent population is susceptible to HAV infection. The potential risk of HAV epidemics still exists. The situation of Turkey, suggested to need for mass immunization. Also, introduction of hepatitis A vaccination into the national immunization schedule of Turkey should be considered.
本血清流行率研究旨在确定土耳其伊兹密尔目前的甲型肝炎血清流行病学情况，并评估 HAV 血清阳性率的流行病学变化。采集了 595 名年龄在 1-60 岁的研究对象的血液样本，用于分析抗-HAV IgG 抗体。本研究结果与 1998 年在同一地点进行的先前研究进行了比较。1998 年至 2008 年间，抗-HAV 的流行率显著下降。虽然本研究中 1-4 岁儿童的抗-HAV 血清阳性率为 4.6%，10-14 岁儿童为 23%，20-29 岁年轻成人为 85%，但先前研究中 1-4 岁年龄组的阳性率为 36%，10-14 岁年龄组为 65%，年轻成人为 95%，表明 HAV 血清阳性率从低龄组向高龄组转移。由于儿童中的 HAV 感染正在减少，土耳其伊兹密尔的易感青少年和年轻成人人数正在增加。大多数青少年人群易感染 HAV。HAV 爆发的潜在风险仍然存在。土耳其的情况表明需要进行大规模免疫接种。此外，应考虑将甲型肝炎疫苗接种纳入土耳其的国家免疫接种计划。
