Department of Psychology and Center for Neurocognitive Research, University of Salzburg, Salzburg, Austria.
Clin Neurophysiol. 2011 Sep;122(9):1744-54. doi: 10.1016/j.clinph.2011.02.009. Epub 2011 Mar 4.
The diagnostic validity of non-phase-locked oscillations (NPLOs) and mismatch negativity (MMN) in an oddball task for assessing attentional reactivity in patients with disordered consciousness was examined.
Patients in a minimally conscious (MCS, n = 6) or vegetative (VS, n = 16) state and healthy controls (n = 15) were assessed. MMN and NPLOs were analyzed with single-subject, non-parametric statistics.
In 11 healthy controls and 2 VS patients, MMN was detected. More subjects showed NPLO differences in the alpha than in the theta or beta frequency ranges. In 14 healthy controls, 4 MCS patients, and 5 VS patients, lower amplitudes after deviants were found in the alpha frequency range. One healthy subject and one VS patient showed higher amplitudes after deviants.
Neither ERPs nor NPLOs could reliably distinguish MCS from VS patients. However, NPLOs were more sensitive than ERPs for detecting significantly different activity, and they possibly identified preserved processing better than ERPs.
Intact neurophysiological attentional responses observed in the NPLOs of VS patients may indicate a need for other diagnostic techniques. Inter-individual differences in the direction of the effect should be considered as normal variance.
研究非锁相振荡（NPLO）和错配负波（MMN）在注意反应性评估中的诊断有效性，用于意识障碍患者。
对最小意识状态（MCS，n=6）或植物状态（VS，n=16）患者和健康对照者（n=15）进行评估。采用单样本、非参数统计学方法分析 MMN 和 NPLO。
在 11 名健康对照者和 2 名 VS 患者中检测到 MMN。与θ或β频率范围相比，更多的受试者在α频率范围内显示出 NPLO 差异。在 14 名健康对照者、4 名 MCS 患者和 5 名 VS 患者中，在α频率范围内，偏离后振幅较低。1 名健康受试者和 1 名 VS 患者表现出偏离后振幅较高。
ERP 和 NPLO 均不能可靠地区分 MCS 和 VS 患者。然而，与 ERP 相比，NPLO 对检测显著不同的活动更敏感，并且它们可能比 ERP 更好地识别保留的处理。
在 VS 患者的 NPLO 中观察到完整的神经生理注意反应，可能表明需要其他诊断技术。效应方向的个体间差异应被视为正常变异。
