耶尔森氏菌生物膜的形成和调控。
Formation and regulation of Yersinia biofilms.
机构信息
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
出版信息
Protein Cell. 2011 Mar;2(3):173-9. doi: 10.1007/s13238-011-1024-3. Epub 2011 Mar 5.
Abstract
Flea-borne transmission is a recent evolutionary adaptation that distinguishes the deadly Yersinia pestis from its progenitor Y. Pseudotuberculosis, a mild pathogen transmitted via the food-borne route. Y. Pestis synthesizes biofilms in the flea gut, which is important for fleaborne transmission. Yersinia biofilms are bacterial colonies surrounded by extracellular matrix primarily containing a homopolymer of N-acetyl-D-glucosamine that are synthesized by a set of specific enzymes. Yersinia biofilm production is tightly regulated at both transcriptional and post-transcriptional levels. All the known structural genes responsible for biofilm production are harbored in both Y. Pseudotuberculosis and Y. Pestis, but Y. Pestis has evolved changes in the regulation of biofilm development, thereby acquiring efficient arthropod-borne transmission.
摘要
跳蚤传播是一种最近进化的适应，将致命的鼠疫耶尔森菌与其前身 Y. 假结核杆菌区分开来，后者是通过食物传播的温和病原体。鼠疫耶尔森菌在跳蚤肠道中合成生物膜，这对于跳蚤传播很重要。耶尔森氏菌生物膜是由细菌菌落组成的，周围是主要由 N-乙酰-D-葡萄糖胺均聚物组成的细胞外基质，这些均聚物由一组特定的酶合成。耶尔森氏菌生物膜的产生在转录和转录后水平受到严格调控。负责生物膜产生的所有已知结构基因都存在于 Y. 假结核杆菌和鼠疫耶尔森菌中，但鼠疫耶尔森菌在生物膜发育的调节方面发生了变化，从而获得了有效的节肢动物传播。
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