State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
J Nat Prod. 2011 May 27;74(5):1028-35. doi: 10.1021/np1009288. Epub 2011 Mar 7.
Fourteen new dibenzocyclooctadiene lignans, ananolignans A-N (1-14), together with five known compounds, were isolated from the seeds of Kadsura ananosma. The structures and absolute configurations of 1-14 were established using a combination of spectroscopic methods including 1D- and 2D-NMR and CD techniques. The biological activity of the isolated lignans was evaluated, and ananolignan F (6) and ananolignan L (12) showed significant neuroprotective effects in an in vitro assay.
十四种新的二苯并环辛二烯木脂素，即 ananolignans A-N（1-14），与五种已知化合物一起，从云南肉豆蔻的种子中分离得到。通过包括 1D- 和 2D-NMR 以及 CD 技术在内的多种光谱方法组合，确定了 1-14 的结构和绝对构型。对分离得到的木脂素进行了生物活性评价，anolignan F（6）和 ananolignan L（12）在体外试验中表现出显著的神经保护作用。
