University of Veterinary Medicine Hannover, Clinic for Poultry, Bünteweg 17, 30559 Hannover, Germany.
Dev Comp Immunol. 2011 Jul;35(7):774-84. doi: 10.1016/j.dci.2011.02.012. Epub 2011 Mar 4.
Gastro-intestinal nematode infections in mammals are associated with local T lymphocyte infiltrations, Th2 cytokine induction, and alterations in epithelial cell secretion and absorption. This study demonstrates that Ascaridia (A.) galli infection in chicken also elicits local gut-associated immune reactions and changes in the intestinal electrogenic nutrient transport. In A. galli-infected birds we observed infiltrations of different T cell populations in the intestinal lamina propria and accumulation of CD4+ lymphocytes in the epithelium. The Th2 cytokines IL-4 and IL-13 dominated the intestinal immune reactions following A. galli infection. A. galli-specific systemic IgY antibodies were detected after two weeks post infection, and did only poorly correlate with detected worm numbers. Electrogenic transport of alanin and glucose was impaired in A. galli-infected chicken. Our data provide circumstantial evidence that local immune responses and electro-physiological intestinal functions may be connected and contribute to the elimination of worm infection.
哺乳动物的胃肠线虫感染与局部 T 淋巴细胞浸润、Th2 细胞因子诱导以及上皮细胞分泌和吸收的改变有关。本研究表明，鸡的寄生蛔虫感染也会引起肠道相关免疫反应和肠道电致营养物质转运的改变。在感染蛔虫的鸟类中，我们观察到肠道固有层中有不同的 T 细胞群浸润，上皮层中 CD4+淋巴细胞积聚。在感染蛔虫后，Th2 细胞因子 IL-4 和 IL-13 主导肠道免疫反应。在感染后两周，检测到针对蛔虫的特异性系统性 IgY 抗体，但与检测到的蠕虫数量相关性较差。电致性转运的丙氨酸和葡萄糖在感染蛔虫的鸡中受到损害。我们的数据提供了间接证据，表明局部免疫反应和电生理肠道功能可能相关，并有助于消除蠕虫感染。
