Equipe de Recherche sur les Relations Matrice Extracellulaire Cellules (Errmece), Institut des Matériaux, Cergy-Pontoise University, 95000 Cergy-Pontoise, France.
Acta Biomater. 2011 Jun;7(6):2418-27. doi: 10.1016/j.actbio.2011.03.002. Epub 2011 Mar 5.
Interpenetrating polymer network (IPN) architectures were conceived to improve the mechanical properties of a fibrin gel. Conditions allowing an enzymatic reaction to create one of the two networks in IPN architecture were included in the synthesis pathway. Two IPN series were carried out, starting from two polyethylene oxide (PEO) network precursors leading to different cross-linking densities of the PEO phase. The fibrin concentration varied from 5 to 20 wt.% in each series. The behavior of these materials during dehydration/hydration cycles was also studied. The mechanical properties of the resulting IPN were characterized in the wet and dry states. These self-supported biomaterials combine the properties of both a protein gel and a synthetic polymer. Finally, cells were grown on PEO/fibrin IPN, indicating that they are non-cytotoxic.
互穿聚合物网络（IPN）结构的设想是为了提高纤维蛋白凝胶的机械性能。在合成途径中包含了允许进行酶反应以形成 IPN 结构中的两种网络之一的条件。进行了两个 IPN 系列，从两种聚环氧乙烷（PEO）网络前体开始，导致 PEO 相的不同交联密度。每个系列中的纤维蛋白浓度从 5 到 20wt.%变化。还研究了这些材料在脱水/水合循环过程中的行为。用湿态和干态对所得 IPN 的机械性能进行了表征。这些自支撑生物材料结合了蛋白质凝胶和合成聚合物的特性。最后，细胞在 PEO/纤维蛋白 IPN 上生长，表明它们没有细胞毒性。
