The University of Texas, Houston, TX, USA.
Integr Cancer Ther. 2011 Sep;10(3):221-33. doi: 10.1177/1534735410392581. Epub 2011 Mar 7.
Fatigue is one of the most frequent and distressing complaints reported by patients with cancer. Describing relationships among disrupted circadian rhythms and cancer-related fatigue is important to the design and testing of interventions that target specific underlying etiology of fatigue. The purpose of this article is to review the literature on whether evidence exists to support the notion that disrupted circadian rhythms provide a mechanism of cancer-related fatigue. Searches were conducted from January 1950 to January 2010, to locate pertinent articles using 4 electronic databases: PubMed, MEDLINE, CINAHL, and Scopus.
After reviewing the articles, 15 were selected as meeting the established criteria of the study and were critiqued. Statistical approaches varied across studies, which may influence generalizability of results. Although commonalities across studies did emerge, there was a lack of consistency in variables studied, and most studies did not identify a theoretical framework. More research needs to be conducted using consistent types and characteristics of disrupted circadian rhythms in relation to fatigue, including temporal relationships between circadian rhythms, fatigue, and cancer.
疲劳是癌症患者最常报告的最令人痛苦的症状之一。描述昼夜节律紊乱与癌症相关疲劳之间的关系对于设计和测试针对疲劳特定潜在病因的干预措施非常重要。本文的目的是综述关于昼夜节律紊乱是否为癌症相关疲劳提供一种机制的证据。从 1950 年 1 月至 2010 年 1 月进行了检索，使用 4 个电子数据库：PubMed、MEDLINE、CINAHL 和 Scopus 查找相关文章。
在对文章进行审查后，选择了 15 篇符合研究既定标准的文章进行了评价。研究中的统计方法各不相同，这可能会影响结果的普遍性。尽管研究之间出现了一些共同点，但在研究的变量方面缺乏一致性，而且大多数研究都没有确定理论框架。需要使用与疲劳有关的一致类型和特征的昼夜节律紊乱进行更多的研究，包括昼夜节律、疲劳和癌症之间的时间关系。
