Solanki Yogendrasinh B, Bhatt Rajendra V
Department of Pharmacology, L. M. College of Pharmacy Nagrangpura, Ahmedabad-380 009 Gujarat, INDIA.
Int J Physiol Pathophysiol Pharmacol. 2010 Jan 1;2(1):57-63.
The present study investigated the effects of antioxidant vitamins along with atorvastatin and atorvastatinniacin combination on diet-induced hypercholesterolemia in rats. High cholesterol diet produced a significant increase in the serum total cholesterol, LDL-C, VLDL-C, TG, atherogenic index and decrease in HDL-C and HDL/LDL ratio. The lipid peroxidation and oxidative stress were significantly high in the hyperlipidemic control group. Atorvastatin improved atherogenic index but not the HDL/LDL ratio whereas atorvastatin-niacin combination improved both atherogenic index and HDL/LDL ratio. However, both atorvastatin and atorvastatin-niacin did not affect antioxidant status significantly. Co-administration of vitamin-E and vitamin-C along with atorvastatin and atorvastatin-niacin have improved serum lipid profile, prevented lipid peroxidation and improved antioxidant status. Addition of β-carotene along with lipid lowering drugs did not show additional benefits on serum lipid profile, lipid peroxidation and antioxidant status. Atorvastatin, atorvastatin-niacin combination when added with anti-oxidant vitamins, increased reduced glutathione level but did not affect MDA level, SOD and catalase activity in the liver tissue. Administration of both vitamin-E and vitamin-C along with atorvastatin-niacin therapy produced a significant improvement in the lipid profile as well as antioxidant status. Addition of β-carotene along with atorvastatin-niacin-vitamin-E-vitamin-C combination improved lipid profile but improvement was not as marked as observed with atorvastatin-niacin-vitamin-E-vitamin-C combination. The same beneficial effects of atorvastatin-niacin combination on lipid profile were not observed when it was combined with anti-oxidant vitamins especially β-carotene. The pro-oxidant role of β-carotene may be responsible for this effect.
本研究调查了抗氧化维生素与阿托伐他汀以及阿托伐他汀 - 烟酸组合对饮食诱导的大鼠高胆固醇血症的影响。高胆固醇饮食使血清总胆固醇、低密度脂蛋白胆固醇（LDL - C）、极低密度脂蛋白胆固醇（VLDL - C）、甘油三酯（TG）、动脉粥样硬化指数显著升高，高密度脂蛋白胆固醇（HDL - C）及HDL/LDL比值降低。高脂血症对照组的脂质过氧化和氧化应激显著升高。阿托伐他汀改善了动脉粥样硬化指数，但未改善HDL/LDL比值，而阿托伐他汀 - 烟酸组合同时改善了动脉粥样硬化指数和HDL/LDL比值。然而，阿托伐他汀和阿托伐他汀 - 烟酸均未显著影响抗氧化状态。维生素E和维生素C与阿托伐他汀及阿托伐他汀 - 烟酸联合使用可改善血清脂质谱，预防脂质过氧化并改善抗氧化状态。降脂药物中添加β - 胡萝卜素对血清脂质谱、脂质过氧化和抗氧化状态未显示出额外益处。阿托伐他汀、阿托伐他汀 - 烟酸组合与抗氧化维生素联合使用时，肝脏组织中还原型谷胱甘肽水平升高，但未影响丙二醛（MDA）水平、超氧化物歧化酶（SOD）和过氧化氢酶活性。维生素E和维生素C与阿托伐他汀 - 烟酸疗法联合使用可显著改善脂质谱及抗氧化状态。阿托伐他汀 - 烟酸 - 维生素E - 维生素C组合中添加β - 胡萝卜素可改善脂质谱，但改善程度不如阿托伐他汀 - 烟酸 - 维生素E - 维生素C组合显著。当阿托伐他汀 - 烟酸组合与抗氧化维生素尤其是β - 胡萝卜素联合使用时，未观察到其对脂质谱的相同有益作用。β - 胡萝卜素的促氧化作用可能是造成这种效应的原因。
