Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.
Macromol Biosci. 2011 Jun 14;11(6):806-13. doi: 10.1002/mabi.201000465. Epub 2011 Mar 7.
A novel PGTA diblock copolymer containing electroactive TEA and mPEG is described. Biodegradable PLLA/PGTA polymer blends are shown to be electroactive. Nanopores of different sizes can be formed on the surface of the polymer blends. An MTT assay shows that the PLLA/PGTA blends exhibited reduced cytotoxicity as compared to TEA due to the introduction of the biocompatible PLLA moiety. Cell culture results show that the cells grow better when they were adhered to the surface of the PLLA/PGTA blends. The 80/20 wt.-% PLLA/PGTA blend shows the best biocompatibility and an electroactivity that accelerates the differentiation of rat C6 glioma cells.
一种新型 PGTA 两亲嵌段共聚物，含有可电化学氧化的 TEA 和 mPEG。研究表明，可生物降解的 PLLA/PGTA 聚合物共混物具有电活性。在聚合物共混物的表面可以形成不同尺寸的纳米孔。MTT 分析表明，与 TEA 相比，由于引入了生物相容性 PLLA 部分，PLLA/PGTA 共混物的细胞毒性降低。细胞培养结果表明，当细胞附着在 PLLA/PGTA 共混物表面时，细胞生长得更好。80/20wt.-% PLLA/PGTA 共混物具有最佳的生物相容性和电活性，可加速大鼠 C6 神经胶质瘤细胞的分化。
