Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA.
J Am Chem Soc. 2011 Mar 30;133(12):4182-5. doi: 10.1021/ja109936h. Epub 2011 Mar 8.
The fabrication of a label-free mass spectrometry and optical detection-based biosensor platform for the detection of low-abundance lipophilic analytes in complex mixtures is described. The biosensor consists of a lipid layer partially tethered to the surface of a gold nanorod. The effectiveness of the biosensor is demonstrated for the label-free detection of a lipophilic drug in aqueous solution and a lipopeptide in serum.
本文描述了一种用于检测复杂混合物中低丰度亲脂性分析物的无标记质谱和光学检测生物传感器平台的制备。该生物传感器由部分固定在金纳米棒表面的脂质层组成。该生物传感器的有效性通过在水溶液中对亲脂性药物和血清中的脂肽进行无标记检测得到了证明。
