Department of Clinical Microbiology, Medical Faculty, Inonu University, Malatya, Turkey.
BMC Public Health. 2011 Mar 8;11:154. doi: 10.1186/1471-2458-11-154.
Extrapulmonary tuberculosis (EPTB) has an increasing rate in Turkey. The reason remains largely unknown. A better understanding of the demographic and microbial characteristics of EPTB in the Turkish population would extend the knowledgebase of EPTB and allow us to develop better strategies to control tuberculosis (TB).
We retrospectively evaluated clinical and laboratory data of 397 bacteriologically-confirmed TB cases diagnosed during an eight year-period using by chi-square analysis and multivariate logistic regression model.
Of the 397 study patients, 103 (25.9%) had EPTB and 294 (74.1%) had pulmonary tuberculosis (PTB). The most commonly seen two types of EPTB were genitourinary TB (27.2%) and meningeal TB (19.4%). TB in bone/joints, pleural cavity, lymph nodes, skin, and peritoneal cavity occurred at a frequency ranging from 9.7% to 10.7%. The age distribution was significantly different (P<0.01) between PTB and EPTB, with patients older than 45 years tending to have an increased risk of EPTB. Furthermore, the distribution of different types of EPTB differed significantly among age groups (P=0.03). Meningeal and bone and/or joint TB were more commonly observed among the male patients, while lymphatic, genitourinary, and peritoneal TB cases were more frequently seen among females. Unique strain infection was statistically significantly associated with EPTB (OR: 2.82, 95% CI [1.59, 5.00])
EPTB accounted for a significant proportion of TB cases in Malatya, Turkey between 2001 and 2007. The current study has provided an insight into the dynamics of EPTB in Malatya, Turkey. However, the risk factors for having EPTB in Malatya, Turkey remain to be assessed in future studies using population-based or randomly selected sample.
在土耳其，肺外结核（EPTB）的发病率呈上升趋势。其原因在很大程度上尚不清楚。更好地了解土耳其人群中 EPTB 的人口统计学和微生物学特征将扩展 EPTB 的知识库，并使我们能够制定更好的控制结核病（TB）的策略。
我们使用卡方分析和多变量逻辑回归模型回顾性评估了在 8 年期间诊断出的 397 例经细菌学证实的结核病患者的临床和实验室数据。
在 397 名研究患者中，有 103 例（25.9%）患有 EPTB，294 例（74.1%）患有肺结核（PTB）。最常见的两种 EPTB 是泌尿生殖系统 TB（27.2%）和脑膜 TB（19.4%）。骨/关节、胸膜腔、淋巴结、皮肤和腹膜腔的 TB 发生率在 9.7%至 10.7%之间。PTB 和 EPTB 之间的年龄分布差异有统计学意义（P<0.01），年龄大于 45 岁的患者发生 EPTB 的风险增加。此外，不同类型的 EPTB 在各年龄组之间的分布差异有统计学意义（P=0.03）。脑膜和骨/关节 TB 更常见于男性患者，而淋巴、泌尿生殖和腹膜 TB 病例更常见于女性。独特菌株感染与 EPTB 有统计学显著相关性（OR：2.82，95%CI[1.59，5.00]）。
在 2001 年至 2007 年期间，EPTB 占土耳其马拉蒂亚结核病病例的很大比例。本研究深入了解了土耳其马拉蒂亚 EPTB 的动态。然而，在未来的研究中，仍需要使用基于人群或随机选择的样本评估土耳其马拉蒂亚发生 EPTB 的风险因素。
