Yamanobe Pediatric Clinic, Yamagata, Japan.
Pediatr Infect Dis J. 2011 Aug;30(8):680-3. doi: 10.1097/INF.0b013e31821608a8.
Saffold virus (SAFV) is a newly discovered virus belonging to the genus Cardiovirus of the family Picornaviridae. Using molecular techniques, SAFV has been detected, although infrequently, in the stools of both healthy and diarrheic children and in respiratory specimens collected from children with respiratory disease. The epidemiology and pathogenicity of SAFV remain unclear.
Between July 2009 and October 2010, nasopharyngeal specimens were collected from children with acute respiratory infections. The collected samples were used to isolate respiratory viruses, including coxsackievirus, by cell culture and were tested for SAFV by reverse transcription-polymerase chain reaction.
SAFV genotype 2 (SAFV2) was detected in 54 (3.5%) of the 1525 children tested. SAFV2 detections showed an epidemic pattern for a 4-month period with a peak in October 2009. The median age of the SAFV2-positive children was 4 years (range: 7 months-16 years). Among the 35 SAFV2-positive children, excluding cases of viral coinfection, 13 (37.1%) had pharyngitis, 12 (34.3%) had tonsillitis, and 8 (22.8%) had herpangina. Bronchitis and gastroenteritis were detected in 1 case each. Fever (temperature, >38°C) was noted in 33 (94.3%) cases. The median duration of fever was 2 days (range: 1-3 days). Diarrhea was observed in 7 (20.0%) children, but watery and frequent diarrhea was not common. The age distribution and clinical diagnoses associated with SAFV2 infections were similar to those observed with coxsackievirus B4 infections, which detections showed an epidemic pattern during the study period.
SAFV2 is a cause of upper respiratory tract illness that exhibits a pathogenicity similar to that of coxsackievirus B.
沙福病毒（SAFV）是一种新发现的病毒，属于小核糖核酸病毒科的小核糖核酸病毒属。应用分子技术，已在健康和腹泻儿童的粪便以及患有呼吸道疾病的儿童的呼吸道标本中，检测到但不常检测到沙福病毒。SAFV 的流行病学和致病性仍不清楚。
2009 年 7 月至 2010 年 10 月，采集急性呼吸道感染患儿的鼻咽标本。采集的标本通过细胞培养分离呼吸道病毒，包括柯萨奇病毒，并通过逆转录聚合酶链反应检测沙福病毒。
在 1525 名受检儿童中，检测到 54 例（3.5%）SAFV2 阳性。SAFV2 检测呈 4 个月流行模式，高峰在 2009 年 10 月。SAFV2 阳性儿童的中位年龄为 4 岁（范围：7 个月至 16 岁）。在 35 例排除病毒混合感染的 SAFV2 阳性儿童中，13 例（37.1%）有咽炎，12 例（34.3%）有扁桃体炎，8 例（22.8%）有疱疹性咽峡炎。1 例有支气管炎，1 例有胃肠炎。33 例（94.3%）有发热（体温>38°C）。发热中位持续时间为 2 天（范围：1-3 天）。7 例（20.0%）患儿出现腹泻，但稀便和频繁腹泻并不常见。SAFV2 感染的年龄分布和临床诊断与 Coxsackievirus B4 感染相似，在研究期间也呈流行模式。
SAFV2 是上呼吸道疾病的病原体，其致病性与柯萨奇病毒 B 相似。
