Department of Chemistry, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Int J Nanomedicine. 2012;7:2829-32. doi: 10.2147/IJN.S31810. Epub 2012 Jun 7.
This report concerns nanofiber composites that incorporate N-heterocyclic carbenes and the use of such composites for testing antimicrobial and antifungal activities. The nanofiber composites were produced by electrospinning mixtures of the gold chloride or gold acetate complexes of a bis(imino)acenaphthene (BIAN)-supported NHC with aqueous solutions of polyvinyl alcohol (PVA). The products were characterized by scanning-electron microscopy, which revealed that nanofibers in the range of 250-300 nm had been produced. The biological activities of the nanofiber composites were tested against two Gram-positive bacteria, six Gram-negative bacteria, and two fungal strains. No activity was evident against the fungal strains. However, the gold chloride complex was found to be active against all the Gram-positive pathogens and one of the Gram-negative pathogens. It was also found that the activity of the produced nanofibers was localized and that no release of the bioactive compound from the nanofibers was evident. The demonstrated antimicrobial activities of these novel nanofiber composites render them potentially useful as wound dressings.
本报告涉及包含氮杂环卡宾的纳米纤维复合材料，以及此类复合材料在测试抗菌和抗真菌活性方面的应用。纳米纤维复合材料是通过静电纺丝金的氯或金的醋酸盐络合物与聚乙烯醇（PVA）的水溶液混合而成的双（亚胺）吖啶（BIAN）-支载氮杂环卡宾制得的。通过扫描电子显微镜对产物进行了表征，结果表明已制备出 250-300nm 范围内的纳米纤维。对纳米纤维复合材料进行了针对两种革兰氏阳性菌、六种革兰氏阴性菌和两种真菌菌株的生物活性测试。对真菌菌株没有表现出活性。然而，发现金的氯络合物对所有革兰氏阳性病原体和一种革兰氏阴性病原体具有活性。还发现，所制备的纳米纤维的活性是定位的，并且没有观察到纳米纤维中生物活性化合物的释放。这些新型纳米纤维复合材料所表现出的抗菌活性使它们有潜力作为伤口敷料使用。
