College of Pharmacy, Zhongnan University, Changsha 410007, China.
Chin J Integr Med. 2011 Feb;17(2):111-5. doi: 10.1007/s11655-011-0638-x. Epub 2011 Mar 9.
To investigate the plasma samples obtained from tumor patients using (1)H nuclear magnetic resonance (NMR) spectroscopy, and find the biochemical foundation of abnormal Savda described in traditional Uyghur medicine.
A total of 170 tumor patients with abnormal Savda syndrome who were confirmed clinically were enrolled in this study, and 50 healthy volunteers were set up as controls. The plasma (1)H NMR spectra were analyzed using the orthogonal projection to latent structure with discriminant analysis (OPLS-DA) method with unit variance scaling. The discriminative significance of the metabolites was determined using the Pearson's product-moment correlation coefficient.
Compared with the healthy controls, the tumor patients with abnormal Savda syndrome had uniformly correlative low levels of leucine, isoleucine, valine, histidine, tyrosine, alanine, glutamine, creatine, inositol, α-glucose, and β-glucose (P<0.05), but had significantly high levels of formate, malonic acid, acetone, acetate, acetoacetate, pyruvate, β-hydroxy butyrate, carnitine and lipidtemns such as very low density lipoprotein, low density lipoprotein and unsaturated lipids (P<0.05).
Tumor patients with abnormal Savda syndrome had similar metabolic changes and characteristics, which indicated a similar pathogenetic process and provides some biochemical basis for traditional Uyghur medicine theory.
利用（1）H 核磁共振（NMR）光谱分析肿瘤患者的血浆样本，寻找传统维吾尔医学中描述的异常沙瓦德的生化基础。
本研究共纳入 170 例经临床证实的异常沙瓦德综合征肿瘤患者，并设 50 例健康志愿者作为对照。采用单位方差标准化的正交投影判别分析（OPLS-DA）方法对血浆（1）H NMR 谱进行分析。采用皮尔逊积矩相关系数确定代谢物的判别意义。
与健康对照组相比，异常沙瓦德综合征肿瘤患者的亮氨酸、异亮氨酸、缬氨酸、组氨酸、酪氨酸、丙氨酸、谷氨酰胺、肌酸、肌醇、α-葡萄糖和β-葡萄糖水平普遍呈低度相关（P<0.05），但甲酸、丙二酸、丙酮、乙酸、乙酰乙酸、丙酮酸、β-羟丁酸、肉碱和脂类（如极低密度脂蛋白、低密度脂蛋白和不饱和脂质）水平显著升高（P<0.05）。
异常沙瓦德综合征肿瘤患者具有相似的代谢变化和特征，提示其具有相似的发病过程，为传统维吾尔医学理论提供了一些生化依据。
