Brandt Benny, Mazaki-Tovi Shali, Hemi Rina, Yinon Yoav, Schiff Eyal, Mashiach Roy, Kanety Hannah, Sivan Eyal
J Perinat Med. 2015 May;43(3):325-31. doi: 10.1515/jpm-2014-0215.
Omentin, a newly identified adipokine, enhances insulin mediated glucose uptake in human adipocytes, thus, inducing systemic insulin-sensitizing effect. The aims of this study were to determine whether circulating maternal omentin levels are associated with insulin resistance indices and to assess which compartment, maternal, fetal, or placental, is the source of omentin in maternal circulation.
Fasting serum glucose, insulin, and omentin were determined in 25 healthy pregnant women at the third trimester, before and 3 days after elective cesarean section. Cord blood omentin was measured in the 25 term neonates. Homeostasis model assessment (HOMA) was used to evaluate insulin sensitivity before and after delivery.
Antepartum maternal omentin levels were negatively correlated with insulin levels (r=-0.41, P=0.04) and positively correlated with insulin sensitivity (HOMA%S; r=0.4, P=0.04). Postpartum omentin levels were negatively correlated with maternal body mass index (r=-0.44, P=0.02). Median maternal omentin levels was comparable before and after delivery (57.2, inter-quartile range: 38.2-76.2 ng/mL vs. 53.4, 39.8-69.4 ng/mL, respectively, P=0.25) and highly correlated (r=0.83, P<0.001). Antepartum maternal and neonatal omentin levels did not differ significantly (fetal: 62.2, 44.3-74.2 ng/mL, P=0.77) and did not correlate (P=0.6).
Circulating maternal omentin levels are correlated with insulin resistance indices, suggesting that this adipokine may play a role in metabolic adaptations of normal gestation. The strong correlation between anteparum and postpartum maternal omentin levels, as well as the lack of association between maternal and neonatal omentin levels, suggest that placental or fetal compartments are unlikely as the main source of circulating maternal omentin.
网膜素是一种新发现的脂肪因子，可增强胰岛素介导的人体脂肪细胞对葡萄糖的摄取，从而产生全身胰岛素增敏作用。本研究旨在确定母体循环中网膜素水平是否与胰岛素抵抗指数相关，并评估母体、胎儿或胎盘哪个部分是母体循环中网膜素的来源。
对25名健康孕妇在妊娠晚期择期剖宫产术前及术后3天测定空腹血糖、胰岛素和网膜素水平。对25名足月新生儿测定脐血网膜素水平。采用稳态模型评估（HOMA）来评估分娩前后的胰岛素敏感性。
产前母体网膜素水平与胰岛素水平呈负相关（r = -0.41，P = 0.04），与胰岛素敏感性呈正相关（HOMA%S；r = 0.4，P = 0.04）。产后网膜素水平与母体体重指数呈负相关（r = -0.44，P = 0.02）。分娩前后母体网膜素水平中位数相当（分别为57.2，四分位间距：38.2 - 76.2 ng/mL与53.4，39.8 - 69.4 ng/mL，P = 0.25）且高度相关（r = 0.83，P < 0.001）。产前母体和新生儿网膜素水平无显著差异（胎儿：62.2，44.3 - 74.2 ng/mL，P = 0.77）且无相关性（P = 0.6）。
母体循环中网膜素水平与胰岛素抵抗指数相关，提示该脂肪因子可能在正常妊娠的代谢适应中发挥作用。产前和产后母体网膜素水平之间的强相关性，以及母体和新生儿网膜素水平之间缺乏关联，提示胎盘或胎儿部分不太可能是母体循环中网膜素的主要来源。
