Division of Geriatrics, School of Medicine, University of South Carolina, Columbia, South Carolina, USA.
J Am Geriatr Soc. 2011 Mar;59(3):495-500. doi: 10.1111/j.1532-5415.2011.03319.x.
To determine whether the presence of high depressive symptoms (Center for Epidemiologic Studies Depression Scale (CES-D) score ≥ 14) diminished physical performance benefits after a comprehensive physical activity intervention in older adults.
A post hoc analysis of data from the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study, a single-blind randomized controlled trial comparing a moderate-intensity physical activity intervention (PA) with a successful aging control (SA).
Multicenter U.S. institutions participating in the LIFE-P trial.
Four hundred twenty-four sedentary, noninstitutionalized adults aged 70 to 89.
Depressive symptoms were assessed using the CES-D. Physical performance tests included the Short Physical Performance Battery (SPPB) and 400-m walk time (400 mw) at baseline and 6 and 12 months.
Of the participants, 15.8% had high depressive symptom scores (CES-D ≥ 14). For participants with low depressive symptoms, SPPB scores improved more in the PA than the SA group over 12 months (adjusted score difference +0.70; P < .001 at 6 months and +0.58; P = .004 at 12 months), and 400 mw times improved in the PA group at 6 months (adjusted score difference -0.41 minutes; P = .02). For participants with high depressive symptoms, the difference in improvement fell short of statistical significance on the SPPB between the PA and SA groups (adjusted score difference +0.76 (P = .18) at 6 months and +0.94 (P = .12) at 12 months).
The presence of high depressive symptoms did not substantially diminish physical performance benefits realized after a PA intervention in sedentary older adults.
确定在老年人中进行综合身体活动干预后，是否存在较高的抑郁症状（流行病学研究中心抑郁量表（CES-D）得分≥14）会降低身体表现的益处。
对生活方式干预和老年人独立先导研究（LIFE-P）数据的事后分析，这是一项比较中等强度身体活动干预（PA）与成功老龄化对照（SA）的单盲随机对照试验。
参与 LIFE-P 试验的美国多中心机构。
424 名久坐、非住院的 70 至 89 岁成年人。
使用 CES-D 评估抑郁症状。身体表现测试包括短期身体表现电池（SPPB）和 400 米步行时间（400 mw），在基线和 6 个月和 12 个月时进行。
参与者中有 15.8%的人存在高抑郁症状评分（CES-D≥14）。对于低抑郁症状的参与者，在 12 个月的时间里，PA 组的 SPPB 评分比 SA 组改善得更多（调整后的评分差异为+0.70；6 个月时 P<0.001，12 个月时 P=0.004），而 400 mw 的时间在 6 个月时在 PA 组中有所改善（调整后的评分差异为-0.41 分钟；P=0.02）。对于高抑郁症状的参与者，PA 组和 SA 组之间 SPPB 的改善差异在统计学上没有显著意义（6 个月时调整后的评分差异为+0.76（P=0.18），12 个月时为+0.94（P=0.12））。
在久坐的老年人中进行 PA 干预后，高抑郁症状的存在并没有显著降低身体表现的益处。
